Xing Yuhang, Qing Xueqin, Xia Hao, Hao Shiqi, Zhu Haofang, He Yiyan, Mao Hongli, Gu Zhongwei
Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, Nanjing Tech University, Nanjing, China.
Department of Pediatrics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Front Chem. 2021 Sep 22;9:744099. doi: 10.3389/fchem.2021.744099. eCollection 2021.
To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide-modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.
为辅助或替代传统的伤口缝合技术，具有优异粘附强度和良好生物相容性的软组织粘合剂在生物医学应用中具有重要意义。在本研究中，开发了一种包含己二酸二酰肼修饰明胶（Gel-ADH）和氧化海藻酸钠（OSA）的可注射水凝胶组织粘合剂。发现这种组织粘合剂具有均匀的结构、合适的溶胀率、良好的可注射性以及优异的血液相容性和细胞相容性。所开发的具有优化成分和浓度的粘合剂的粘附能力强于市售粘合剂猪纤维蛋白密封剂套件。所有这些结果表明，所开发的水凝胶是一种很有前景的软组织粘合剂候选材料。
