Xue Chen, Cai Xiaolu, Jia Junjun
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Cell Dev Biol. 2021 Sep 23;9:709069. doi: 10.3389/fcell.2021.709069. eCollection 2021.
A growing number of studies are reporting important roles played by long non-coding RNAs (lncRNAs) in various pathological and physiological processes. LncRNAs are implicated in numerous genomic regulatory functions at different levels, including regulation of transcription, post-transcriptional processes, genomic stability, and epigenetic genome modifications. Double homeobox A pseudogene 8 (DUXAP8), a novel lncRNA, has been reported to be involved in many cancers, including gastric, colorectal, esophageal, bladder, oral, ovarian, lung, and pancreatic cancers as well as hepatocellular carcinoma (HCC). DUXAP8 plays specific oncogenic roles numerous malignancies promoting pathways. DUXAP8 is frequently dysregulated in multiple cancers, acting as a sponge to downregulate various tumor-suppressing microRNA activities. In this review, we comprehensively explore DUXAP8 expression and prognosis across cancer types, and systematically summarize current evidence concerning the functions and molecular mechanisms of DUXAP8 in tumorigenesis and progression. We conclude that DUXAP8 is a potential biomarker and therapeutic target for multiple cancers.
越来越多的研究报道了长链非编码RNA（lncRNA）在各种病理和生理过程中发挥的重要作用。lncRNA在不同水平上涉及众多基因组调控功能，包括转录调控、转录后过程、基因组稳定性和表观遗传基因组修饰。双同源盒A假基因8（DUXAP8）是一种新型lncRNA，据报道它参与了多种癌症，包括胃癌、结直肠癌、食管癌、膀胱癌、口腔癌、卵巢癌、肺癌、胰腺癌以及肝细胞癌（HCC）。DUXAP8在众多恶性肿瘤促进途径中发挥特定的致癌作用。DUXAP8在多种癌症中经常失调，充当海绵以下调各种肿瘤抑制性微小RNA的活性。在本综述中，我们全面探讨了DUXAP8在不同癌症类型中的表达和预后，并系统总结了目前关于DUXAP8在肿瘤发生和进展中的功能及分子机制的证据。我们得出结论，DUXAP8是多种癌症的潜在生物标志物和治疗靶点。
