Husband A J, Monié H J, Gowans J L
Ciba Found Symp. 1977(46):29-54. doi: 10.1002/9780470720288.ch3.
The IgA-secreting cells in the lamina propria of the small intestine are derived from large lymphocytes which enter the blood by way of the thoracic duct and then migrate into the gut where they complete their differentiation into plasma cells. Three aspects of this cellular traffic have been examined in rats. 1. The cells in thoracic duct lymph which give rise to IgA-secreting cells in the lamina propria are among those which carry surface IgA. Blast cells lacking surface immunoglobulin migrate mainly into the Peyer's patches and do not contribute to the IgA response. 2. Studies on a secondary antibody response to cholera toxoid, in which the challenge was given into a Thiry-Vella loop, showed that the antibody-containing blast cells in thoracic duct lymph were derived from Peyer's patches. The mesenteric nodes contributed little, if anything, to the cellular response in the lymph. 3. The idea that secretory component is a signal for the emigration of large lymphocytes from the blood into the lamina propria lacks experimental support. Secretory component does not bind to the IgA on the surface of thoracic duct cells. On the other hand, antigen in the gut may play an important part in immobilizing large lymphocytes in the lamina propria once they have migrated.
小肠固有层中分泌 IgA 的细胞源自大淋巴细胞，这些大淋巴细胞通过胸导管进入血液，然后迁移至肠道，在那里它们分化为浆细胞。已在大鼠中研究了这种细胞运输的三个方面。1. 在固有层中产生分泌 IgA 细胞的胸导管淋巴细胞是携带表面 IgA 的细胞。缺乏表面免疫球蛋白的母细胞主要迁移至派尔集合淋巴结，对 IgA 反应无贡献。2. 对霍乱类毒素的二次抗体反应的研究（其中将激发物注入 Thiry-Vella 肠袢）表明，胸导管淋巴中含抗体的母细胞源自派尔集合淋巴结。肠系膜淋巴结对淋巴中的细胞反应贡献极小。3. 分泌成分是大淋巴细胞从血液迁移至固有层的信号这一观点缺乏实验支持。分泌成分不与胸导管细胞表面的 IgA 结合。另一方面，肠道中的抗原可能在大淋巴细胞迁移至固有层后使其固定方面起重要作用。
