Speirs R L
Arch Oral Biol. 1986;31(6):373-81. doi: 10.1016/0003-9969(86)90160-3.
By means of mini-osmotic pumps implanted into rats (110-240 g body wt), steady-state fluoride levels in serum were raised throughout a 21-day period. Small volumes of a fluoride solution twice daily by gastric intubation produced transient elevations of serum fluoride, base-line values being reached within 6 h. The calculated mean fluoride increments in serum were similar to those observed in the infused rats through the daily dosages of fluoride were about 1.0 and 0.625 mg F/kg respectively. The amounts of fluoride incorporated into periosteal bone, incisor dentine and newly-formed enamel were generally greater in the infused than intubated rats, but these differences were reduced or absent when fluoride concentrations were related to the serum-fluoride concentrations. The results from a few rats given 1.25 mg F/kg per day by continuous infusion confirmed that the amounts of fluoride incorporated into mineralized tissues were closely related to the serum-fluoride levels. Rats were also given these fluoride supplements from the 10th day of pregnancy until parturition. The mode of fluoride administration did not affect the amount of fluoride incorporated into the tissues of the mothers or into the skeletal ash of the pups when the results were expressed in relation to maternal serum-fluoride levels.
通过将微型渗透泵植入大鼠体内（体重110 - 240克），在21天的时间里使血清中的氟化物达到稳态水平。每天通过胃管给予少量氟化物溶液两次会使血清氟化物短暂升高，6小时内达到基线值。通过计算得出，血清中氟化物的平均增量与在注入氟化物的大鼠中观察到的相似，尽管每日氟化物剂量分别约为1.0毫克氟/千克和0.625毫克氟/千克。与经胃管给药的大鼠相比，注入氟化物的大鼠中，骨膜骨、切牙牙本质和新形成的牙釉质中所含的氟化物量通常更多，但当将氟化物浓度与血清氟化物浓度相关联时，这些差异会减小或不存在。对几只通过连续输注给予每天1.25毫克氟/千克的大鼠的研究结果证实，矿化组织中所含的氟化物量与血清氟化物水平密切相关。大鼠还在怀孕第10天至分娩期间接受这些氟化物补充剂。当根据母体血清氟化物水平来表示结果时，氟化物的给药方式不会影响母体组织或幼崽骨骼灰分中所含的氟化物量。
