1 型糖尿病患者使用连续血糖监测仪的患者特征和临床结局:来自 T1D Exchange 真实世界观察性研究的数据。

Patient Demographics and Clinical Outcomes Among Type 1 Diabetes Patients Using Continuous Glucose Monitors: Data From T1D Exchange Real-World Observational Study.

机构信息

Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

T1D Exchange, Boston, MA, USA.

出版信息

J Diabetes Sci Technol. 2023 Mar;17(2):322-328. doi: 10.1177/19322968211049783. Epub 2021 Oct 9.

Abstract

BACKGROUND

The benefits of Continuous Glucose Monitoring (CGM) on glycemic management have been demonstrated in numerous studies; however, widespread uptake remians limited. The aim of this study was to provide real-world evidence of patient attributes and clinical outcomes associated with CGM use across clinics in the U.S. based T1D Exchange Quality Improvement (T1DX-QI) Collaborative.

METHOD

We examined electronic Health Record data from eight endocrinology clinics participating in the T1DX-QI Collaborative during the years 2017-2019.

RESULTS

Among 11,469 type 1 diabetes patients, 48% were CGM users. CGM use varied by race/ethnicity with Non-Hispanic Whites having higher rates of CGM use (50%) compared to Non-Hispanic Blacks (18%) or Hispanics (38%). Patients with private insurance were more likely to use CGM (57.2%) than those with public insurance (33.3%) including Medicaid or Medicare. CGM users had lower median HbA1c (7.7%) compared to nonusers (8.4%). Rates of diabetic ketoacidosis (DKA) and severe hypoglycemia were significantly higher in nonusers compared to CGM users.

CONCLUSION

In this real-world study of patients in the T1DX-QI Collaborative, CGM users had better glycemic control and lower rates of DKA and severe hypoglycemia (SH) events, compared to nonusers; however, there were significant sociodemographic disparities in CGM use. Quality improvement and advocacy measures to promote widespread and equitable CGM uptake have the potential to improve clinical outcomes.

摘要

背景

多项研究已经证明了连续血糖监测(CGM)在血糖管理方面的益处;然而,其广泛应用仍然受到限制。本研究旨在基于 T1D 交换质量改进(T1DX-QI)协作,提供美国各诊所 CGM 使用与患者特征和临床结局相关的真实世界证据。

方法

我们检查了 2017 年至 2019 年期间参与 T1DX-QI 协作的 8 个内分泌诊所的电子健康记录数据。

结果

在 11469 名 1 型糖尿病患者中,有 48%的患者使用 CGM。CGM 的使用因种族/族裔而异,非西班牙裔白人的 CGM 使用率(50%)高于非西班牙裔黑人(18%)或西班牙裔(38%)。有私人保险的患者比有公共保险(包括医疗补助或医疗保险)的患者更有可能使用 CGM(57.2%)。CGM 用户的中位 HbA1c(7.7%)低于非用户(8.4%)。与 CGM 用户相比,非用户的糖尿病酮症酸中毒(DKA)和严重低血糖(SH)发生率显著更高。

结论

在 T1DX-QI 协作的患者真实世界研究中,与非用户相比,CGM 用户的血糖控制更好,DKA 和严重低血糖(SH)事件发生率更低;然而,CGM 的使用存在显著的社会人口统计学差异。质量改进和宣传措施,以促进广泛和公平地采用 CGM,有可能改善临床结局。

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