Trisomy 22--a new abnormality found in acute leukemia characterized by eosinophilia and monocytoid blasts expressing immature differentiation antigens.

Bone marrow cells from three patients with acute myeloid leukemia, with marrow eosinophilia and monocytoid blasts, showed a new nonrandom chromosomal abnormality, trisomy 22. In two patients the classification of leukemia was M4 and in the third patient M2 (FAB classification). Pretreatment bone marrows in these patients revealed 31%, 30%, and 4% eosinophils, respectively. Blast cells isolated from peripheral blood were Ia-positive and expressed immature monocyte lineage antigens (U26, U28, U48) in 26%-92% of cells. All three patients had a population of bone marrow cells characterized by an extra chromosome #22. One patient also had inversion of chromosome #16. Trisomy 22, bone marrow eosinophilia, and monocytoid blasts displaying early monocyte differentiation antigens may represent a new subgroup of patients with acute myeloid leukemia.