Aga Khan University Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2021 Aug;71(Suppl 5)(8):S83-S86.
To determine the experience at the Aga Khan University Hospital in diagnosing and treating adult patients with primary lymphoma of bone.
All patients with Primary lymphoma of bone (PLB) that were diagnosed and/or treated at Aga Khan University Hospital, Karachi from 2005 to 2019 were included as part of this study.
There were 17 patients with PLB including 13 (76.5%) males and 4 (23.5%) females with a mean age of 44 ± 16.5 years. Nine patients were between 30-59 years of age at diagnosis. The mean follow-up time of patients was 80±46.7 months. Six patients had tumours of pelvic bone followed by tibia (5) and femur (4). Four patients had a pathological fracture at the time of presentation whereas 2 (11.8%) required surgical fixation of the pathological fracture. The stage of the tumour was based on Ann Arbor classification. Nine (52.9%) cases had Stage 1 disease, 7 (41.2%) had stage IV disease with metastasis in extra nodal tissues. As for treatment, every patient received chemotherapy whereas 5 (29.4%) received adjuvant radiotherapy. Complete remission in the size of the tumour was seen in 11 (64.7%) patients while 6 (35.3%) had partial remission. Post-treatment, 4 (23.5%) patients expired. The mean Overall Survival (OS) time was 80.18 ± 46.71months with a survival rate of 76.5.
Primary lymphoma of the bone can be treated with medical regime and good prophylactic surgeries to avoid pathological fracture such as intramedullary nailing.
确定 Aga Khan 大学医院在诊断和治疗成人原发性骨淋巴瘤患者方面的经验。
本研究纳入了 2005 年至 2019 年在卡拉奇 Aga Khan 大学医院诊断和/或治疗的所有原发性骨淋巴瘤（PLB）患者。
共纳入 17 例原发性骨淋巴瘤患者，其中男 13 例（76.5%），女 4 例（23.5%），平均年龄 44±16.5 岁。9 例患者在诊断时年龄为 30-59 岁。患者的平均随访时间为 80±46.7 个月。6 例患者肿瘤位于骨盆骨，其次是胫骨（5 例）和股骨（4 例）。4 例患者在就诊时发生病理性骨折，其中 2 例（11.8%）需要手术固定病理性骨折。肿瘤分期基于 Ann Arbor 分类。9 例（52.9%）患者为 1 期疾病，7 例（41.2%）患者为 4 期疾病，伴淋巴结外组织转移。治疗方面，所有患者均接受化疗，5 例（29.4%）接受辅助放疗。11 例（64.7%）患者肿瘤完全缓解，6 例（35.3%）患者部分缓解。治疗后，4 例（23.5%）患者死亡。总生存（OS）时间的平均值为 80.18±46.71 个月，生存率为 76.5%。
原发性骨淋巴瘤可以通过药物治疗和良好的预防性手术来治疗，以避免病理性骨折，如髓内钉。
