大花茉莉提取物对盐酸/乙醇诱导的小鼠胃黏膜溃疡的胃保护作用。
Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice.
作者信息
Zhang Yizi, Sun Lingli, Lai Xingfei, Peng Xingjia, Wen Shuai, Zhang Zhenbiao, Xie Yinzheng, Li Qiuhua, Chen Ruohong, Zheng Xi, Zhang Kun, Sun Shili, Li Dongli
机构信息
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.
出版信息
Biomed Pharmacother. 2021 Dec;144:112268. doi: 10.1016/j.biopha.2021.112268. Epub 2021 Oct 9.
Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.
大花茉莉是一种用于治疗肝炎和胃炎的药用植物，但其对胃肠道黏膜损伤的保护作用机制尚待阐明。在本研究中，我们分析了大花茉莉花朵中的四种不同提取物和两种化合物对盐酸/乙醇诱导的小鼠胃溃疡模型的影响。花朵提取物通过增加前列腺素E2的产生和抗氧化酶的活性，同时抑制活性氧（ROS）生成、脂质过氧化、凋亡相关蛋白、促炎细胞因子和一氧化氮（NO）的产生，减轻了胃黏膜溃疡。
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