Laboratory of Pharmacology and Molecular Chemistry - LFQM, Regional University of Cariri - URCA, Crato, CE 63105-000, Brazil.
Antibiotics department - DB, Federal University of Pernambuco - UFPE, Recife, PE 50670-901, Brazil.
Phytomedicine. 2021 Dec;93:153768. doi: 10.1016/j.phymed.2021.153768. Epub 2021 Sep 26.
Terpinolene, a monoterpene that is naturally found in a variety of herbs, is widely used as a flavoring agent in the industry. Although it's well established in the literature that terpinolene is an important component of plant extracts, the biological properties and the potential therapeutic use of this compound remain poorly explored.
This work aimed to answer the following guiding question: "What are the biological activities of terpinolene demonstrated through in silico, in vitro, and in vivo assays?".
A systematic review was carried out in four electronic databases (Embase, Web of Science, Scopus, and PubMed) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, using the following search terms: terpinolene "AND" activity "OR" properties "OR" therapeutic "OR" treatment. This search included manuscripts published between 1960 and June 2020. Study selection was conducted by two independent reviewers according to predefined criteria.
The initial search found a total of 2449 articles. However, only 57 of them were selected as they met the inclusion criteria and answered the guiding question. The analysis of these studies indicated that terpinolene presents a series of biological effects, from which the antioxidant, larvicide, and insecticide activities stand out. Despite the evidence demonstrating that terpinolene has the potential to be used in a broad pharmacological context, the mechanisms underlying its cellular and molecular effects remain to be better elucidated. In addition, the in vivo efficacy and safety of the administration of this compound have been poorly evaluated through either preclinical and clinical trials. Therefore, this study highlights the importance of characterizing the biological aspects and mechanisms of action of this natural compound.
The data summarized in the present systematic review demonstrates the pharmacological potential of terpinolene. Nevertheless, most studies included in this review provide a superficial characterization of terpinolene biological effects and therefore, further research elucidating its mechanism of action and potential therapeutic benefits through preclinical and clinical trials are required. Nevertheless, due to its wide range of different biological activities, terpinolene will certainly attract the interest of scientific research, which could significantly contribute to the development of new products with both therapeutic and environmental applications.
萜品烯是一种天然存在于多种草药中的单萜，广泛用作工业中的香料。尽管萜品烯是植物提取物的重要成分已在文献中得到充分证实，但该化合物的生物学特性和潜在治疗用途仍未得到充分探索。
本研究旨在回答以下指导问题：“萜品烯通过计算机模拟、体外和体内试验表现出哪些生物学活性？”。
根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，在四个电子数据库（Embase、Web of Science、Scopus 和 PubMed）中进行了系统评价，使用以下搜索词：萜品烯“和”活性“或”特性“或”治疗“或”治疗“。该搜索包括 1960 年至 2020 年 6 月期间发表的手稿。根据预设标准，由两名独立评审员进行研究选择。
最初的搜索共发现 2449 篇文章。然而，只有 57 篇文章被选中，因为它们符合纳入标准并回答了指导问题。对这些研究的分析表明，萜品烯具有一系列生物学作用，其中抗氧化剂、杀幼虫剂和杀虫剂活性尤为突出。尽管有证据表明萜品烯具有广泛的药理学应用潜力，但仍需要更好地阐明其细胞和分子作用的机制。此外，通过临床前和临床试验评估，该化合物的体内疗效和安全性评估较差。因此，本研究强调了表征这种天然化合物的生物学方面和作用机制的重要性。
本系统评价总结的数据表明了萜品烯的药理潜力。然而，本综述中包含的大多数研究仅对萜品烯的生物学作用进行了肤浅的描述，因此需要通过临床前和临床试验进一步研究阐明其作用机制和潜在的治疗益处。然而，由于其广泛的不同生物学活性，萜品烯肯定会引起科学研究的兴趣，这将为开发具有治疗和环境应用的新产品做出重大贡献。
