Ortega-Espinosa Anaí, Martínez-Benaiges Miguel Ángel, Rojas-Pineda Norma Angélica, Morfín-Maciel Blanca María
Hospital Star Médica Infantil Privado, Ciudad de México, México.
Rev Alerg Mex. 2021 Jul-Sep;68(3):209-213. doi: 10.29262/ram.v68i3.901.
Heiner syndrome is a very rare but reversible lung disease caused by non-IgE-mediated hypersensitivity to cow's milk proteins resulting in an atypical pulmonary disease in babies and infants. Very few cases have been reported. Due to its heterogeneous manifestations, the diagnosis can be delayed since it can occur with chronic or recurrent infections of the upper or lower respiratory tract, fever, growth failure, or gastrointestinal symptoms. Pulmonary infiltrates can be mistaken for pneumonia, but Heiner's syndrome is refractory to antibiotic treatment.
We describe the case of a 1-month-old newborn baby whose main symptom was hematemesis, which is a rare symptom. The diagnosis was confirmed with the complete disappearance of the symptoms when milk and dairy products were strictly avoided.
The prognosis is favorable if a milk-free diet is begun early. Most children will tolerate cow´s milk within a few years.
海纳综合征是一种非常罕见但可逆转的肺部疾病，由非IgE介导的对牛奶蛋白过敏引起，导致婴儿和幼儿出现非典型肺部疾病。报道的病例极少。由于其表现多样，诊断可能会延迟，因为它可能伴有上呼吸道或下呼吸道的慢性或反复感染、发热、生长发育迟缓或胃肠道症状。肺部浸润可能被误诊为肺炎，但海纳综合征对抗生素治疗无效。
我们描述了一名1个月大新生儿的病例，其主要症状是呕血，这是一种罕见症状。当严格避免食用牛奶和奶制品后症状完全消失，从而确诊。
如果早期开始无奶饮食，预后良好。大多数儿童在几年内将能够耐受牛奶。
