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海纳综合征的一种不同临床表现:弥漫性肺泡出血导致大量咯血和呕血的病例。

A different clinical presentation of Heiner syndrome: The case of diffuse alveolar hemorrhage causing massive hemoptysis and hematemesis.

作者信息

Koc Ayse Selcan, Sucu Asena, Celik Umit

机构信息

Department of Radiology, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey.

Department of Pediatric, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey.

出版信息

Respir Med Case Rep. 2019 Jan 23;26:206-208. doi: 10.1016/j.rmcr.2019.01.019. eCollection 2019.

DOI:10.1016/j.rmcr.2019.01.019
PMID:30733916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6354653/
Abstract

Heiner syndrome is a non-IgE-mediated hypersensitivity to cow's milk, which often causes pulmonary disease in infants and young children. Patients often have symptoms of chronic or recurrent upper or lower respiratory tract infection. It has been reported that the Heiner's syndrome can cause recurrent pulmonary hemorrhage, and it is difficult to differentiate from the entity of idiopathic pulmonary hemosiderosis, another disease with recurrent pulmonary hemorrhage of unknown etiology usually occurring in the older children. Acute respiration is a rare problem in Heiner syndrome, which usually has symptoms and signs of chronic respiratory disease. In this case report, we present a 6-month-old patient who was admitted to our hospital with massive hemoptysis, hematemesis, and deep anemia.

摘要

海纳综合征是一种对牛奶的非IgE介导的超敏反应,常导致婴幼儿肺部疾病。患者常有慢性或复发性上呼吸道或下呼吸道感染症状。据报道,海纳综合征可导致反复肺出血,且难以与特发性肺含铁血黄素沉着症相鉴别,后者是另一种病因不明的反复肺出血疾病,通常发生于大龄儿童。急性呼吸问题在海纳综合征中较为罕见,该病通常具有慢性呼吸道疾病的症状和体征。在本病例报告中,我们介绍了一名6个月大的患者,该患者因大量咯血、呕血和重度贫血入院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/b73726084bc1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/acbe3759d306/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/cda1bdb50203/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/b73726084bc1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/acbe3759d306/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/cda1bdb50203/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e71b/6354653/b73726084bc1/gr3.jpg

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Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines update - III - Cow's milk allergens and mechanisms triggering immune activation.牛奶过敏诊断与行动依据(DRACMA)指南更新——三、牛奶过敏原及触发免疫激活的机制
World Allergy Organ J. 2022 Sep 15;15(9):100668. doi: 10.1016/j.waojou.2022.100668. eCollection 2022 Sep.
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本文引用的文献

1
Milk-induced pulmonary disease in infants (Heiner syndrome).婴儿牛奶诱发的肺部疾病(海纳综合征)。
Pediatr Allergy Immunol. 2005 Sep;16(6):545-52. doi: 10.1111/j.1399-3038.2005.00291.x.
2
Multiple precipitins to cow's milk in chronic respiratory disease. A syndrome including poor growth, gastrointestinal symptoms, evidence of allergy, iron deficiency anemia, and pulmonary hemosiderosis.慢性呼吸道疾病中对牛奶的多种沉淀素。一种包括生长发育迟缓、胃肠道症状、过敏迹象、缺铁性贫血和肺含铁血黄素沉着症的综合征。
Am J Dis Child. 1962 May;103:634-54.
海纳综合征与牛奶过敏:当前证据的最新综述。
Nutrients. 2021 May 18;13(5):1710. doi: 10.3390/nu13051710.