吲哚洛尔（心得静）对20例哮喘患者呼吸功能的影响。

Influence of pindolol (Visken) on respiratory function in 20 asthmatic patients.

作者信息

Christensen C C, Boye N P, Erikson H, Hansen G

出版信息

Eur J Clin Pharmacol. 1978 Mar 17;13(1):9-12. doi: 10.1007/BF00606674.

Abstract

The effect of a single oral dose of pindolol on bronchi was studied in a double-blind cross-over trial in 20 adult patients, most of whom had moderate bronchial asthma. A single dose of pindolol 5 mg, sufficient to cause a significant fall in heart rate and blood pressure at rest, did not produce a significant fall in the forced expiratory volume (FEV1.0). However, two patients showed marked deterioration in lung function after pindolol. A conventional therapeutic dose of salbutamol by inhalation produced a significant increase in ventilatory function relative to placebo, but it did not outweigh the bronchial effect of pindolol.

摘要

在一项双盲交叉试验中，对20名成年患者（其中大多数患有中度支气管哮喘）研究了单次口服吲哚洛尔对支气管的影响。单次服用5毫克吲哚洛尔，足以使静息心率和血压显著下降，但并未使用力呼气量（FEV1.0）显著下降。然而，两名患者在服用吲哚洛尔后肺功能明显恶化。吸入常规治疗剂量的沙丁胺醇相对于安慰剂使通气功能显著增加，但并未超过吲哚洛尔对支气管的影响。