β受体阻滞剂与哮喘
Beta-blockers and asthma.
作者信息
Decalmer P B, Chatterjee S S, Cruickshank J M, Benson M K, Sterling G M
出版信息
Br Heart J. 1978 Feb;40(2):184-9. doi: 10.1136/hrt.40.2.184.
Abstract
In a single-blind, randomised, crossover study in 10 asthmatic patients, the effects of approximately equipotent oral doses of 3 cardioselective beta-blockers-atenolol (100 mg), metoprolol (100 mg), and acebutolol (300 mg)-and 4 non-cardioselective beta-blockers-proranolol (100 mg), oxprenolol (100 mg), pindolol (5 mg), and timolol (10 mg) upon FEV1 were compared. All drugs, except pindolol, produced a significant reduction in standing pulse rate and prevented an increase in heart rate after inhaled isoprenaline (1500 microgram). All drugs caused a fall in FEV1 but only atenolol did not differ significantly from placebo in this respect. The bronchodilator response to inhaled isoprenaline was blocked by the 4 non-cardioselective drugs; the 3 cardioselective agents permitted some bronchodilatation, but only atenolol did not differ from placebo.
摘要
在一项针对10名哮喘患者的单盲、随机、交叉研究中，比较了口服剂量大致相当的3种心脏选择性β受体阻滞剂（阿替洛尔100毫克、美托洛尔100毫克和醋丁洛尔300毫克）以及4种非心脏选择性β受体阻滞剂（普萘洛尔100毫克、氧烯洛尔100毫克、吲哚洛尔5毫克和噻吗洛尔10毫克）对第一秒用力呼气量（FEV1）的影响。除吲哚洛尔外，所有药物均使静息脉率显著降低，并防止吸入异丙肾上腺素（1500微克）后心率增加。所有药物均导致FEV1下降，但在这方面只有阿替洛尔与安慰剂无显著差异。4种非心脏选择性药物阻断了对吸入异丙肾上腺素的支气管扩张反应；3种心脏选择性药物允许一定程度的支气管扩张，但只有阿替洛尔与安慰剂无差异。
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本文引用的文献
1
A comparison of the effect on airway resistance of a new beta blocking drug, ICI.50,172 and propranolol.一种新型β受体阻滞剂ICI.50,172与普萘洛尔对气道阻力影响的比较。
Br J Anaesth. 1968 Jul;40(7):508-10. doi: 10.1093/bja/40.7.508.
2
Beta-adrenergic blocking drugs.β-肾上腺素能阻断药
Br Med J. 1971 Jun 12;2(5762):652. doi: 10.1136/bmj.2.5762.652-b.
3
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Br Med J. 1973 Jan 20;1(5846):138-42. doi: 10.1136/bmj.1.5846.138.
4
Human pharmacokinetic and pharmacodynamic studies on the atenolo (ICI 66,082), a new cardioselective beta-adrenoceptor blocking drug.对新型心脏选择性β-肾上腺素受体阻断药阿替洛尔（ICI 66,082）的人体药代动力学和药效学研究。
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5
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Am J Cardiol. 1975 Oct 31;36(5):653-69. doi: 10.1016/0002-9149(75)90168-x.
6
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J Clin Invest. 1975 Sep;56(3):719-24. doi: 10.1172/JCI108143.
7
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8
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Br Med J. 1976 Jul 3;2(6026):7-9. doi: 10.1136/bmj.2.6026.7.
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