CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
ACS Sens. 2020 Mar 27;5(3):601-619. doi: 10.1021/acssensors.9b02039. Epub 2020 Mar 3.
Molecularly imprinted polymers (MIPs) receive extensive interest, owing to their structure predictability, recognition specificity, and application universality as well as robustness, simplicity, and inexpensiveness. Surface-enhanced Raman scattering (SERS) is regarded as an ideal optical detection candidate for its unique features of fingerprint recognition, nondestructive property, high sensitivity, and rapidity. Accordingly, MIP based SERS (MIP-SERS) sensors have attracted significant research interest for versatile applications especially in the field of chemo- and bioanalysis, showing excellent identification and detection performances. Herein, we comprehensively review the recent advances in MIP-SERS sensors construction and applications, including sensing principles and signal enhancement mechanisms, focusing on novel construction strategies and representative applications. First, the basic structure of the MIP-SERS sensors is briefly outlined. Second, novel imprinting strategies are highlighted, mainly including multifunctional monomer imprinting, dummy template imprinting, living/controlled radical polymerization, and stimuli-responsive imprinting. Third, typical application of MIP-SERS sensors in chemo/bioanalysis is summarized from both small and macromolecular aspects. Lastly, the challenges and perspectives of the MIP-SERS sensors are proposed, orienting sensitivity improvement and application expanding.
分子印迹聚合物（MIPs）由于其结构可预测性、识别特异性和应用通用性以及稳健性、简单性和经济性而受到广泛关注。表面增强拉曼散射（SERS）因其独特的指纹识别、非破坏性、高灵敏度和快速性而被认为是理想的光学检测候选者。因此，基于 MIP 的 SERS（MIP-SERS）传感器因其在化学和生物分析等多个领域的广泛应用而引起了极大的研究兴趣，表现出优异的识别和检测性能。本文全面综述了 MIP-SERS 传感器的构建和应用的最新进展，包括传感原理和信号增强机制，重点介绍了新颖的构建策略和代表性应用。首先，简要概述了 MIP-SERS 传感器的基本结构。其次，重点介绍了新颖的印迹策略，主要包括多功能单体印迹、虚拟模板印迹、活性/可控自由基聚合和刺激响应印迹。第三，从小分子和大分子两个方面总结了 MIP-SERS 传感器在化学/生物分析中的典型应用。最后，提出了 MIP-SERS 传感器的挑战和展望，旨在提高灵敏度和扩大应用范围。
