Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Addiction. 2022 Apr;117(4):1071-1078. doi: 10.1111/add.15716. Epub 2021 Nov 3.
Electronic cigarette use has escalated rapidly in recent years, particularly among youth. Little is known about the genetic influences on e-cigarette use. This study aimed to determine whether genetic risk for regular use of combustible cigarettes or for number of cigarettes smoked per day confers risk for ever e-cigarette use or frequency of e-cigarette use.
DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We used data from 9541 young adults from the Spit for Science longitudinal cohort study (2011-2019). Polygenic scores (PGS) of regular combustible cigarette use (PGS-RCU) and cigarettes per day (PGS-CPD) were constructed using summary statistics from the two largest available genome-wide association study (GWAS) meta-analysis of European ancestry and East Asian ancestry of combustible cigarette use and used to test whether the PGS of RCU or CPD predicted lifetime e-cigarette use and frequency of past 30-day e-cigarette use in a diverse sample of young adults of African (AFR), Admixed American (AMR), East Asian (EAS), European (EUR), and South Asian (SAS) ancestry.
The PGS-RCU was associated with lifetime e-cigarette use in the EUR sample (OR = 1.27, 95% CI = 1.19-1.36, P = 7.53 × 10 ), but not in the other subsamples (ps > 0.12). This association remained significant after excluding regular combustible cigarette smokers (OR = 1.21, 95% CI = 1.12-1.31, P = 3.36 × 10 ). There was no statistically significant association between PGS-CPD and lifetime e-cigarette use and neither the PGS-RCU nor the PGS-CPD were associated with frequency of e-cigarette use in the past 30 days in any of the subsamples.
Genetic factors associated with regular combustible cigarette use appear to be associated with ever e-cigarette use in young adults. We did not find evidence for shared genetic factors influencing heaviness of use of combustible cigarettes and current e-cigarette use frequency.
近年来，电子烟的使用迅速增加，尤其是在年轻人中。对于电子烟使用的遗传影响知之甚少。本研究旨在确定常规使用可燃香烟或每天吸烟数量的遗传风险是否会导致曾经使用电子烟或电子烟使用频率的风险。
设计、地点、参与者和测量：我们使用了来自 Spit for Science 纵向队列研究（2011-2019 年）的 9541 名年轻人的数据。使用来自两个最大的可用全基因组关联研究（GWAS）对可燃香烟使用的欧洲和东亚血统的汇总统计数据构建了常规可燃香烟使用的多基因评分（PGS-RCU）和每天香烟数量的多基因评分（PGS-CPD），并用于测试 RCU 或 CPD 的 PGS 是否可以预测终生电子烟使用和不同种族（AFR、混合美国血统（AMR）、东亚（EAS）、欧洲（EUR）和南亚（SAS））的年轻成年人过去 30 天电子烟使用频率。
PGS-RCU 与 EUR 样本中的终生电子烟使用相关（OR = 1.27，95%CI = 1.19-1.36，P = 7.53×10 ），但在其他样本中没有（ps > 0.12）。在排除常规可燃香烟吸烟者后，这种关联仍然显著（OR = 1.21，95%CI = 1.12-1.31，P = 3.36×10 ）。PGS-CPD 与终生电子烟使用之间没有统计学上的显著关联，PGS-RCU 或 PGS-CPD 也与任何样本中过去 30 天电子烟使用频率均无关。
与常规可燃香烟使用相关的遗传因素似乎与年轻人中的曾经使用电子烟有关。我们没有发现影响可燃香烟使用量和当前电子烟使用频率的共同遗传因素的证据。
