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补充 Djulis 对氧化应激和紫外线辐射引起的细胞损伤的作用:对健康受试者皮肤抗氧化状态和衰老的影响。

Djulis supplementation against oxidative stress and ultraviolet radiation-induced cell damage: The influence of antioxidant status and aging of skin in healthy subjects.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

出版信息

J Cosmet Dermatol. 2022 Jul;21(7):2945-2953. doi: 10.1111/jocd.14482. Epub 2021 Oct 12.

DOI:10.1111/jocd.14482
PMID:34636463
Abstract

BACKGROUND

Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may protect skin from photoaging, but conclusive experiments have not been carried out.

OBJECTIVE

This investigation evaluates the effects of djulis extract as a functional supplement.

PATIENTS/METHODS: In this study, the effects of djulis functional drinks on the free radical scavenging activities, promotion of collagen synthesis and protection against oxidative stress and the effects of ultraviolet B (UVB)-irradiated of pUC119 DNA were explored. Thirty healthy subjects (aged 35-55 years old) were randomly allocated to djulis or placebo drinks groups (50 ml of a djulis/placebo drink daily for 8 weeks for each subject) in a double-blind crossover study.

RESULTS

The regular consumption of the djulis functional drinks significantly increased levels of the serum biochemical superoxide dismutase (SOD) and catalase (+9.5% and +124.8%) after 8 weeks, relative to baseline controls. The improvements in skin moisture, brightness, elasticity, crow's feet, texture, wrinkles, pores, and collagen content after 8 weeks in the djulis group were +13.3%, +3.8%, +13.2%, -21.8%, -12.1%, -11.0%, -1.4%, and +33.7%, respectively, relative to the baseline without treatment.

CONCLUSIONS

These work findings suggest the daily consumption of djulis drinks can protect the skin against oxidative stress-induced damage, delay skin aging and improve skin conditions.

摘要

背景

蕺菜(Chenopodium formosanum Koidz.)是一种谷物食品,其抗氧化和色素成分可能有助于保护皮肤免受光老化,但尚未进行确凿的实验。

目的

本研究评估蕺菜提取物作为功能性补充剂的效果。

患者/方法:在这项研究中,探讨了蕺菜功能饮料对自由基清除活性、促进胶原蛋白合成以及对氧化应激和紫外线 B(UVB)照射的 pUC119 DNA 的保护作用。30 名健康受试者(年龄 35-55 岁)被随机分配到蕺菜或安慰剂饮料组(每位受试者每天饮用 50ml 蕺菜/安慰剂饮料,持续 8 周),采用双盲交叉研究。

结果

常规饮用蕺菜功能饮料 8 周后,血清生化超氧化物歧化酶(SOD)和过氧化氢酶水平分别显著升高(分别增加 9.5%和 124.8%)。8 周后,蕺菜组皮肤水分、光泽度、弹性、鱼尾纹、纹理、皱纹、毛孔和胶原蛋白含量的改善分别为+13.3%、+3.8%、+13.2%、-21.8%、-12.1%、-11.0%、-1.4%和+33.7%,与未经治疗的基线相比。

结论

这些研究结果表明,每天饮用蕺菜饮料可以保护皮肤免受氧化应激引起的损伤,延缓皮肤衰老,改善皮肤状况。

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