School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China.
Planta Med. 2013 Nov;79(16):1572-5. doi: 10.1055/s-0033-1350896. Epub 2013 Sep 30.
Arigsugacin I (1), a new α-pyrone meroterpene, along with two known compounds, arigsugacins F (2) and territrem B (3), were isolated from the mangrove endophytic fungus Penicillium sp. sk5GW1L from Kandelia candel. Their structures were identified through mass spectrometry and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. The absolute configuration of compound 2 was first reported by using X-ray copper radiation. Compounds 1-3 showed inhibitory activities against acetylcholinesterase with IC50 values of 0.64 ± 0.08 µM, 0.37 ± 0.11 µM, and 7.03 ± 0.20 nM, respectively.
阿瑞古萨辛 I（1），一种新的α-吡喃酮倍半萜，与两种已知化合物，阿瑞古萨辛 F（2）和地衣萜 B（3）一起，从红树林内生真菌青霉 sp. sk5GW1L 中分离得到。它们的结构通过质谱和 NMR 实验确定，化合物 1 的绝对构型通过低温（100 K）单晶 X 射线衍射与 Cu Kα 辐射进一步确认。化合物 2 的绝对构型首次通过 X 射线铜辐射报道。化合物 1-3 对乙酰胆碱酯酶表现出抑制活性，IC50 值分别为 0.64±0.08μM、0.37±0.11μM 和 7.03±0.20nM。
