MATBIOM, Universidad de Medellín, Medellín, Colombia.
GI2B, Instituto Tecnológico Metropolitano, Medellín, Colombia.
PLoS One. 2021 Oct 12;16(10):e0258313. doi: 10.1371/journal.pone.0258313. eCollection 2021.
Particulate matter (PM) is considered the most severe environmental pollution problem due to its serious effects on human health associated with an increased risk of cardiovascular morbidity and mortality. In this work, a physicochemical characterization of PM10 from the city of Medellin was developed. The results evince that lead (Pb) is one of the most abundant elements since it is present in all analyzed samples. Therefore, Pb was chosen to perform an in-silico study to assess its effects on atrial arrhythmias generation. For this purpose, we developed a model representing the Pb2+ blocking effect on the L-type calcium channel. This formulation was incorporated in a human atrial cell mathematical model and in 2D and 3D models of human atria. The simulations showed a proarrhythmic effect at high Pb2+ concentrations, through shortening of action potential duration inducing the generation of reentrant activity and atrial flutter. The results contribute to the knowledge about the cardiac physiopathological processes, triggered by lead as one of the main PM10 metal components of air pollution, that yields the generation of arrhythmias.
颗粒物（PM）被认为是最严重的环境污染问题，因为它对人类健康造成严重影响，增加了心血管发病率和死亡率的风险。在这项工作中，对麦德林市的 PM10 进行了物理化学特性分析。结果表明，铅（Pb）是最丰富的元素之一，因为它存在于所有分析的样本中。因此，选择 Pb 进行计算机模拟研究，以评估其对心房性心律失常发生的影响。为此，我们开发了一个代表 Pb2+ 对 L 型钙通道阻断作用的模型。该配方被纳入人心房细胞数学模型以及人心房的 2D 和 3D 模型中。模拟结果显示，在高 Pb2+浓度下具有致心律失常作用，通过缩短动作电位持续时间诱导折返活动和心房扑动的发生。这些结果有助于了解心脏生理病理过程，这些过程是由空气污染中 PM10 的主要金属成分之一铅引发的，导致心律失常的发生。
