Division of Environmental Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, United States.
Department of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
J Hazard Mater. 2022 Feb 15;424(Pt B):127381. doi: 10.1016/j.jhazmat.2021.127381. Epub 2021 Sep 30.
This study evaluated the 12-year trends in serum levels of 28 organochlorine pesticides (OCPs) in 880 adults living in Seoul, Korea. The OCP levels decreased from 2006 to 2017, and p,p'-dichlorodiphenyldichloroethylene was a predominant compound. OCP levels were higher in females than in males, and showed positive associations with BMI and age. The OCP concentrations had inverted U-shaped associations with low-density lipoprotein cholesterol and total cholesterol. Concentrations of β-hexachlorocyclohexane were significantly higher in patients with hypertension than in participants that were normotensive. OCP levels showed positive associations with uric acid, creatinine, and thyroid-stimulating hormone, but negative associations with free thyroxine. Participants with diabetes had significantly higher OCP levels than those without it. Principal component analysis suggested possible differences in disease manifestation depending on the composition of OCPs. These results suggest that OCPs might disturb renal transport and thyroid homeostasis. To our knowledge, the inverted U-shaped associations of heptachlor epoxide and endosulfan with cholesterol, the epidemiological associations of trans-nonachlor and endosulfan with thyroid hormones, and the association of p,p'-DDE with hyperuricemia have not been previously reported in general population. This is the first long-term study to show trends of 28 OCPs in serum and associations with various health indicators in Korea.
本研究评估了韩国首尔 880 名成年人血清中 28 种有机氯农药 (OCPs) 12 年的变化趋势。从 2006 年到 2017 年，OCP 水平逐渐降低，其中 p,p'-二氯二苯二氯乙烯是主要化合物。女性的 OCP 水平高于男性，且与 BMI 和年龄呈正相关。OCP 浓度与低密度脂蛋白胆固醇和总胆固醇呈倒 U 型相关。与正常血压参与者相比，高血压患者体内的β-六氯环己烷浓度显著更高。OCP 水平与尿酸、肌酐和促甲状腺激素呈正相关，与游离甲状腺素呈负相关。患有糖尿病的参与者的 OCP 水平明显高于没有糖尿病的参与者。主成分分析表明，OCP 的组成可能会导致不同的疾病表现。这些结果表明，OCP 可能会干扰肾脏转运和甲状腺的稳态。据我们所知，七氯环氧化物和硫丹与胆固醇的倒 U 型关系、反式-非六氯环己烷和硫丹与甲状腺激素的流行病学关系，以及 p,p'-DDE 与高尿酸血症的关系以前在一般人群中并未报道过。这是第一项在韩国进行的长期研究，旨在显示血清中 28 种 OCP 的趋势及其与各种健康指标的关联。
