Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Texas, Houston, USA.
CA Cancer J Clin. 2023 Jul-Aug;73(4):425-442. doi: 10.3322/caac.21773. Epub 2023 Feb 24.
Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studies or in which clinical observations become the basis for animal studies. The conference Translating Energy Balance from Bench to Communities: Application of Parallel Animal-Human Studies in Cancer, held in July 2021, convened investigators from basic, translational/clinical, and population science research to share knowledge, examples of successful parallel studies, and strong research to move the field of energy balance and cancer toward practice changes. This review summarizes key topics discussed to advance research on the role of energy balance, including physical activity, body composition, and dietary intake, on cancer development, cancer outcomes, and healthy survivorship.
迄今为止，能量平衡和癌症研究的进展主要发生在啮齿动物或患者的孤立工作中。然而，从平行研究中可以获得实质性的益处，其中动物模型为临床和人群研究的设计提供信息，或者临床观察成为动物研究的基础。2021 年 7 月举行的“将能量平衡从实验室转化为社区：癌症中平行动物-人类研究的应用”会议召集了来自基础、转化/临床和人群科学研究的研究人员，分享知识、成功的平行研究案例以及强有力的研究，以推动能量平衡和癌症领域朝着实践改变的方向发展。本综述总结了讨论的关键主题，以推进关于能量平衡（包括体力活动、身体成分和饮食摄入）在癌症发展、癌症结果和健康生存方面的作用的研究。
