Yang Xiang-Xiang, Luo Hui, Zhang Jia-Jun, Ge Heng, Ge Liang
Department of Medical Imaging, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou 450003, Henan Province, China.
World J Radiol. 2025 Apr 28;17(4):105722. doi: 10.4329/wjr.v17.i4.105722.
Ultra-high dose rate flash radiotherapy (FLASH-RT) has attracted wide attention in the field of radiotherapy in recent years. For FLASH-RT, radiation is delivered at a very high dose rate [usually thousands of times compared with conventional radiotherapy (CONV-RT)] in an extremely short time. This novel irradiation technique shows a protective effect on normal tissues, also known as the flash effect. At the same time, FLASH-RT is comparable to CONV-RT in terms of tumor-killing efficacy. As basic research dedicates to uncover the mechanisms by which FLASH-RT reduces radiation-induced normal tissue damage, clinical trials of FLASH-RT have been gradually conducted worldwide. This article systematically reviews the evidence of the feasibility and safety of FLASH-RT in clinical practice and offers insights into the future translation of this technology in clinic.
近年来，超高剂量率闪疗（FLASH-RT）在放射治疗领域引起了广泛关注。对于FLASH-RT，辐射在极短时间内以非常高的剂量率（通常与传统放疗（CONV-RT）相比数千倍）进行输送。这种新型照射技术对正常组织显示出保护作用，也称为闪效。同时，FLASH-RT在肿瘤杀伤疗效方面与CONV-RT相当。随着基础研究致力于揭示FLASH-RT减少辐射诱导的正常组织损伤的机制，FLASH-RT的临床试验已在全球范围内逐步开展。本文系统回顾了FLASH-RT在临床实践中可行性和安全性的证据，并对该技术未来在临床中的转化提供了见解。
