Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China.
School of Public Health, Xiamen University, Xiamen 361000, China.
Molecules. 2022 Jun 17;27(12):3879. doi: 10.3390/molecules27123879.
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β (Aβ) plaques and neurofibrillary tangles of Tau proteins. Thus, researchers have been devoting tremendous efforts to developing and designing new molecules for the early diagnosis of AD and curative purposes. Curcumin and its scaffold have fluorescent and photochemical properties. Mounting evidence showed that curcumin scaffold had neuroprotective effects on AD such as anti-amyloidogenic, anti-inflammatory, anti-oxidative and metal chelating. In this review, we summarized different curcumin derivatives and analyzed the in vitro and in vivo results in order to exhibit the applications in AD diagnosis, therapeutic monitoring and therapy. The analysis results showed that, although curcumin and its analogues have some disadvantages such as short wavelength and low bioavailability, these shortcomings can be conquered by modifying the structures. Curcumin scaffold still has the potential to be a multifunctional tool for AD research, including AD diagnosis and therapy.
阿尔茨海默病（AD）是最常见的神经退行性疾病之一，由多种因素引起，其特征是两种组织病理学标志：淀粉样β（Aβ）斑块和 Tau 蛋白神经原纤维缠结。因此，研究人员一直在致力于开发和设计新的分子，以实现 AD 的早期诊断和治疗目的。姜黄素及其骨架具有荧光和光化学性质。越来越多的证据表明，姜黄素骨架对 AD 具有神经保护作用，如抗淀粉样变性、抗炎、抗氧化和金属螯合作用。在这篇综述中，我们总结了不同的姜黄素衍生物，并分析了它们的体外和体内结果，以展示它们在 AD 诊断、治疗监测和治疗中的应用。分析结果表明，尽管姜黄素及其类似物存在一些缺点，如短波长和低生物利用度，但通过修饰结构可以克服这些缺点。姜黄素骨架仍然有潜力成为 AD 研究的多功能工具，包括 AD 的诊断和治疗。
