Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Department of Anatomy, Keimyung University School of Medicine, Dageu 42601, Korea.
Int J Mol Sci. 2021 Sep 29;22(19):10509. doi: 10.3390/ijms221910509.
Kahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed to investigate the molecular mechanism by which kahweol induces apoptosis in HCC cells. The Src pathway is associated with apoptosis in cancer. In this study, we found that kahweol induces apoptosis by inhibiting phosphorylation of Src, and also inhibiting p-mTOR and p-STAT3. Therefore, we suggest that kahweol is a potent inhibitor of HCC cell growth.
卡瓦胡椒醇是一种咖啡特有的二萜，可诱导人癌细胞凋亡，并且已经鉴定出卡瓦胡椒醇介导凋亡的一些靶标。然而，卡瓦胡椒醇在肝癌（HCC）细胞中的具体凋亡作用和作用机制尚不清楚。本研究旨在探讨卡瓦胡椒醇诱导 HCC 细胞凋亡的分子机制。Src 途径与癌症中的细胞凋亡有关。在本研究中，我们发现卡瓦胡椒醇通过抑制 Src 的磷酸化诱导细胞凋亡，并且还抑制 p-mTOR 和 p-STAT3。因此，我们认为卡瓦胡椒醇是 HCC 细胞生长的有效抑制剂。
