Medical Biochemistry Medical College, Jagiellonian University, 31-034 Cracow, Poland.
Nutrition and Health Research Group 1 A-B, Department of Population Health, Luxembourg Institute of Health, 1 A-B, rue Thomas Edison, L-23 1445 Strassen, Luxembourg.
Int J Mol Sci. 2021 Sep 29;22(19):10537. doi: 10.3390/ijms221910537.
Prostate cancer (PC) is the second most common tumor in males. The search for appropriate therapeutic options against advanced PC has been in process for several decades. Especially after cessation of the effectiveness of hormonal therapy (i.e., emergence of castration-resistant PC), PC management options have become scarce and the prognosis is poor. To overcome this stage of disease, an array of natural and synthetic substances underwent investigation. An interesting and promising class of compounds constitutes the derivatives of natural retinoids. Synthesized on the basis of the structure of retinoic acid, they present unique and remarkable properties that warrant their investigation as antitumor drugs. However, there is no up-to-date compilation that consecutively summarizes the current state of knowledge about synthetic retinoids with regard to PC. Therefore, in this review, we present the results of the experimental studies on synthetic retinoids conducted within the last decade. Our primary aim is to highlight the molecular targets of these compounds and to identify their potential promise in the treatment of PC.
前列腺癌（PC）是男性中第二常见的肿瘤。几十年来，人们一直在寻找针对晚期 PC 的合适治疗选择。特别是在激素治疗（即去势抵抗性 PC 的出现）失效后，PC 的治疗选择变得稀缺，预后较差。为了克服这一疾病阶段，大量的天然和合成物质接受了研究。一类有趣且有前途的化合物是天然视黄醇衍生物。它们是基于视黄酸的结构合成的，具有独特而显著的特性，这使其成为抗肿瘤药物的研究对象。然而，目前还没有最新的综述连续总结关于合成视黄醇在 PC 方面的最新知识状况。因此，在这篇综述中，我们展示了过去十年中关于合成视黄醇的实验研究结果。我们的主要目的是强调这些化合物的分子靶点，并确定它们在治疗 PC 方面的潜在前景。
