International Clinical Research Center (ICRC), St Anne's University Hospital (FNUSA), 656 92 Brno, Czech Republic.
Department of Public Health, Faculty of Medicine, Masaryk University, 656 91 Brno, Czech Republic.
Int J Environ Res Public Health. 2021 Sep 29;18(19):10251. doi: 10.3390/ijerph181910251.
Cardiorespiratory fitness (CRF) is a strong independent predictor of morbidity and mortality. However, there is no recent information about the impact of CRF on cardiometabolic risk specifically in Central and Eastern Europe, which are characterized by different biological and social determinants of health. In this cross-sectional study normative CRF values were proposed and the association between CRF and cardiometabolic outcomes was evaluated in an adult Czechian population. In 2054 participants (54.6% females), median age 48 (IQR 19 years), the CRF was predicted from a non-exercise equation. Multivariable-adjusted logistic regressions were carried out to determine the associations. Higher CRF quartiles were associated with lower prevalence of hypertension, type 2 diabetes (T2D) and dyslipidemia. Comparing subjects within the lowest CRF, we see that those within the highest CRF had decreased chances of hypertension (odds ratio (OR) = 0.36; 95% CI: 0.22-0.60); T2D (OR = 0.16; 0.05-0.47), low HDL-c (OR = 0.32; 0.17-0.60), high low-density lipoprotein (OR = 0.33; 0.21-0.53), high triglycerides (OR = 0.13; 0.07-0.81), and high cholesterol (OR = 0.44; 0.29-0.69). There was an inverse association between CRF and cardiometabolic outcomes, supporting the adoption of a non-exercise method to estimate CRF of the Czech population. Therefore, more accurate cardiometabolic studies can be performed incorporating the valuable CRF metric.
心肺适能（CRF）是发病率和死亡率的强有力的独立预测因子。然而，在中欧和东欧，关于 CRF 对心血管代谢风险的影响尚无最新信息，这些地区的健康生物学和社会决定因素不同。在这项横断面研究中，提出了正常的 CRF 值，并评估了捷克成年人中 CRF 与心血管代谢结局之间的关系。在 2054 名参与者（54.6%为女性）中，中位年龄为 48（IQR 为 19 岁），CRF 由非运动方程预测。进行了多变量调整的逻辑回归以确定关联。较高的 CRF 四分位数与高血压、2 型糖尿病（T2D）和血脂异常的患病率较低相关。比较 CRF 最低四分位的参与者，我们发现 CRF 最高四分位的参与者患高血压的几率降低（比值比（OR）=0.36；95%CI：0.22-0.60）；T2D（OR=0.16；0.05-0.47），低高密度脂蛋白胆固醇（OR=0.32；0.17-0.60），高低密度脂蛋白（OR=0.33；0.21-0.53），高甘油三酯（OR=0.13；0.07-0.81）和高胆固醇（OR=0.44；0.29-0.69）。CRF 与心血管代谢结局之间呈负相关，支持采用非运动方法来估计捷克人群的 CRF。因此，可以进行更准确的心血管代谢研究，纳入有价值的 CRF 指标。
