Lafont S, André C, André F, Gillon J, Fargier M C
J Exp Med. 1982 May 1;155(5):1573-8. doi: 10.1084/jem.155.5.1573.
We have investigated the possibility of oral administration of ovalbumin (OVA) to prevent a secondary antibody response and interrupt reaginic antibody production. Repeated feeding seems necessary for both. Quality of results was dependent on the number of ingestions. Differences in abrogation of antibody response between mice strains were observed. Best results were obtained with AKR mice, good suppression was seen in C3H strain, and inconsistent results were obtained with DBA/2. 10 OVA oral doses were necessary to prevent a secondary antibody response in parenterally immunized mice, but 4 doses interrupted reaginic production in sensitized AKR mice. These results demonstrate that antigen feeding can prevent a secondary antibody response and interrupt reaginic antibody production.
我们研究了口服卵清蛋白（OVA）以预防二次抗体反应并中断反应素抗体产生的可能性。两者似乎都需要重复喂食。结果的质量取决于摄入次数。观察到不同小鼠品系在抗体反应消除方面存在差异。AKR小鼠获得了最佳结果，C3H品系有良好的抑制效果，而DBA/2小鼠的结果不一致。对于经肠外免疫的小鼠，需要10次OVA口服剂量来预防二次抗体反应，但4次剂量就能中断致敏AKR小鼠的反应素产生。这些结果表明，抗原喂食可以预防二次抗体反应并中断反应素抗体产生。
