Holmdahl R, Jansson L, Andersson M, Larsson E
Department of Medical and Physiological Chemistry, University of Uppsala, Sweden.
Immunology. 1988 Oct;65(2):305-10.
The MHC restriction of the antibody response and development of arthritis after immunization with autologous or heterologous type II collagens in mice have been investigated. Mice from three different H-2q-carrying strains (DBA/1, NFR/N and B10.G) with different non-MHC genes, as well as B10-congenic strains carrying wild type H-2q-related or H-2r haplotypes, were susceptible for collagen arthritis. All strains tested developed an antibody response cross-reacting with autologous type II collagen after immunization with heterologous type II collagen; H-2q predisposes for a high response against chick, rat and bovine type II collagen, H-2r and H-2b for a high response against bovine type II collagen. Only mouse strains with H-2q, H-2r, H-2w3 or H-2w17 were responders to mouse type II collagen, and only these strains developed arthritis after immunization with heterologous or autologous type II collagens. These findings indicate that the ability to mount an immune response against autologous type II collagen is a prerequisite for the susceptibility to collagen arthritis. A cross-reactive autoimmune response after immunization with various heterologous type II collagen may enhance further the development of arthritis.
对小鼠用自体或异体II型胶原免疫后抗体反应的MHC限制以及关节炎的发展进行了研究。来自三种不同携带H-2q的品系（DBA/1、NFR/N和B10.G）且具有不同非MHC基因的小鼠，以及携带野生型H-2q相关或H-2r单倍型的B10同基因品系，对胶原性关节炎敏感。所有测试品系在用异体II型胶原免疫后均产生了与自体II型胶原交叉反应的抗体反应；H-2q使小鼠对鸡、大鼠和牛II型胶原产生高反应，H-2r和H-2b使小鼠对牛II型胶原产生高反应。只有具有H-2q、H-2r、H-2w3或H-2w17的小鼠品系对小鼠II型胶原产生反应，并且只有这些品系在用异体或自体II型胶原免疫后才会发生关节炎。这些发现表明，对自体II型胶原产生免疫反应的能力是对胶原性关节炎易感性的先决条件。用各种异体II型胶原免疫后产生的交叉反应性自身免疫反应可能会进一步促进关节炎的发展。
