Amukarimi Shukufe, Mozafari Masoud
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran 1449614535, Iran.
Bioengineering (Basel). 2022 Mar 5;9(3):107. doi: 10.3390/bioengineering9030107.
In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.
近几十年来，我们目睹了永久性生物材料使用方面的巨大变化。镁（Mg）及其合金在不释放有毒降解产物的情况下自行降解的内在能力，已在生物医学领域引发了广泛应用，包括心血管支架、肌肉骨骼及矫形应用。使用可生物降解的镁生物材料后，患者将不再遭受二次手术及手术疼痛。即便如此，这些生物材料的主要缺点是高腐蚀速率以及在生理环境中的意外降解。鉴于可生物降解的镁基植入物预期要呈现可控降解并符合特定应用的要求，人们采用了各种技术，如设计镁合金和改变表面特性，来调整降解速率。本文总结了镁在生理环境中降解的一些基本原理和具体情况，并介绍了控制镁基生物材料降解行为的方法。
