Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.
Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu Province 215006, China.
Colloids Surf B Biointerfaces. 2020 Jun;190:110911. doi: 10.1016/j.colsurfb.2020.110911. Epub 2020 Feb 27.
Enhanced corrosion resistance and accelerated new bone formation are desired to make Mg and its alloys to be ideal candidate for bone biomaterial. For this purpose, a CDHA/MgF bi-layer coating was prepared on high purity Mg by a combination of fluoride treatment and hydrothermal treatment. The coating exhibited a nanoscale surface topography. Enhanced adhesion strength and corrosion resistance was obtained for the CDHA/MgF bi-layer coating. In vitro cell experiment showed that the adhesion, proliferation and differentiation of MG63 cells were significantly improved on Mg with CDHA/MgF coating compared to that on Mg with HA coating and MgF coating. In conclusion, this study provides a promising surface modification method for Mg metal with enhanced corrosion resistance and superior osteogenic bioactivity.
为了使镁及其合金成为理想的骨生物材料，需要提高其耐腐蚀性和促进新骨形成。为此，通过氟化物处理和水热处理相结合，在高纯镁上制备了 CDHA/MgF 双层涂层。该涂层具有纳米级表面形貌。CDHA/MgF 双层涂层提高了涂层的结合强度和耐腐蚀性。体外细胞实验表明，与 HA 涂层和 MgF 涂层相比，CDHA/MgF 涂层的镁具有更好的 MG63 细胞黏附、增殖和分化能力。综上所述，本研究为提高耐腐蚀性和优异成骨生物活性的镁金属提供了一种有前途的表面改性方法。
