急性心肌梗死患者血清骨保护素水平与冠状动脉疾病严重程度的关联
Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction.
作者信息
Cottin Yves, Issa Rany, Benalia Mourad, Mouhat Basile, Meloux Alexandre, Tribouillard Laura, Bichat Florence, Rochette Luc, Vergely Catherine, Zeller Marianne
机构信息
Cardiology Department, CHU Dijon Bourgogne, 21000 Dijon, France.
Equipe d'Accueil (EA 7460), Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Faculté des Sciences de Santé Université de Bourgogne-Franche Comté, 7 Bd Jeanne d'Arc, 21000 Dijon, France.
出版信息
J Clin Med. 2021 Sep 23;10(19):4326. doi: 10.3390/jcm10194326.
BACKGROUND
Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification.
AIM
We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI).
METHODS
Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3-6)), medium (11 (9-13)) and high (20 (18-23)) tertiles of SYNTAX score.
RESULTS
Among the 378 patients included, there was a gradual increase in age, rate of diabetes, anterior wall location, and a reduction in left ventricular ejection fraction across the SYNTAX tertiles. OPG levels significantly increased across the tertiles (962 (782-1497), 1240 (870-1707), and 1464 (1011-2129) pg/mL, respectively ( < 0.001)). In multivariate analysis, OPG [OR(CI95%): 2.10 (1.29-3.49) 0.003], were associated with the high SYNTAX group, beyond hypercholesterolemia, CV history and reduced glomerular filtration rate.
CONCLUSION
We found an association between OPG levels and coronary lesions complexity patients with acute MI.
背景
骨保护素（OPG）是肿瘤坏死因子（TNF）超家族的一种糖蛋白，是血管钙化的主要生物标志物之一。
目的
我们旨在评估急性心肌梗死（MI）患者血清OPG水平与冠状动脉病变程度之间的关联。
方法
纳入因急性MI住院并接受冠状动脉造影的连续患者。计算SYNTAX评分以评估冠状动脉疾病的严重程度。将研究人群按SYNTAX评分的低（5（3 - 6））、中（11（9 - 13））和高（20（18 - 23））三分位数进行分析。
结果
在纳入的378例患者中，随着SYNTAX三分位数的升高，年龄、糖尿病发生率、前壁位置逐渐增加，左心室射血分数降低。OPG水平在三分位数间显著升高（分别为962（782 - 1497）、1240（870 - 1707）和1464（1011 - 2129）pg/mL，<0.001）。在多变量分析中，除高胆固醇血症、心血管病史和肾小球滤过率降低外，OPG[比值比（95%置信区间）：2.10（1.29 - 3.49），P = 0.003]与高SYNTAX组相关。
结论
我们发现急性MI患者的OPG水平与冠状动脉病变复杂性之间存在关联。
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