蛋白激酶C在大鼠海马切片中的易位

Translocation of protein kinase C in rat hippocampal slices.

作者信息

Zatz M

出版信息

Brain Res. 1986 Oct 15;385(1):174-8. doi: 10.1016/0006-8993(86)91562-3.

Abstract

Tumor-promoting phorbol esters specifically activate protein kinase C and mimic the effects of neurotransmitters in certain systems. Treatment of hippocampal slices with phorbol dibutyrate caused translocation of protein kinase C activity from cytoplasm to membranes. Experiments with carbachol, norepinephrine, glutamate, KCl, and LiCl failed to demonstrate a similar translocation. Translocation more readily provides an index of protein kinase C involvement for phorbol esters than for other agents in hippocampus.

摘要

促肿瘤佛波酯可特异性激活蛋白激酶C，并在某些系统中模拟神经递质的作用。用二丁酰佛波酯处理海马切片会导致蛋白激酶C活性从细胞质转移至细胞膜。用卡巴胆碱、去甲肾上腺素、谷氨酸、氯化钾和氯化锂进行的实验未能证明有类似的转移。与海马体中的其他物质相比，转移更易于提供佛波酯参与蛋白激酶C作用的指标。