Kaneko Y, Hayashi Y, Sakurai M
Cancer Genet Cytogenet. 1981 Nov;4(3):227-35. doi: 10.1016/0165-4608(81)90016-9.
Sixteen of the 17 patients with acute lymphocytic leukemia (ALL) were revealed to have chromosome abnormalities in their leukemic cells. Of nine children, six had modal chromosome numbers between 50 and 59; these patients and one additional patient with a pseudodiploid karyotype have achieved and retained a complete remission. The only patient without chromosome abnormalities achieved a remission, but had a relapse and died. The only child who expired without achieving a remission had 47 chromosomes in his leukemic cells. Of eight adults, none had the hyperdiploidy seen in the children. The four with hypo-or pseudodiploidy failed to achieve a complete remission. One patient had 47 chromosomes in his leukemic cells, and this patient and the remaining three, all with ploidy abnormalities, achieved a complete remission, but a relapse occurred and they died. The chromosomal abnormalities were very extensive in most cases, many patients having marker chromosomes of an unknown origin. Four patients clearly exhibited karyotypic evolution when they relapsed. The patients with hyperdiploidy had a better prognosis, and those with pseudodiploidy had a poorer prognosis. The role of individual chromosome aberrations, however, remains to be elucidated.
17例急性淋巴细胞白血病（ALL）患者中，有16例的白血病细胞存在染色体异常。在9名儿童患者中，6名患者的染色体众数在50至59之间；这些患者以及另一名假二倍体核型的患者已实现并维持完全缓解。唯一没有染色体异常的患者实现了缓解，但复发并死亡。唯一未实现缓解就死亡的儿童，其白血病细胞中有47条染色体。在8名成年患者中，没有一人出现儿童患者中所见的超二倍体情况。4名亚二倍体或假二倍体患者未实现完全缓解。一名患者的白血病细胞中有47条染色体，该患者以及其余3名均有倍性异常的患者实现了完全缓解，但复发并死亡。在大多数情况下，染色体异常非常广泛，许多患者有来源不明的标记染色体。4名患者复发时明显出现了核型演变。超二倍体患者预后较好，假二倍体患者预后较差。然而，单个染色体畸变的作用仍有待阐明。
