肿瘤相关巨噬细胞的免疫调节活性
Immunoregulating activity of tumor-associated macrophages.
作者信息
Dougherty G J, McBride W H
出版信息
Cancer Immunol Immunother. 1986;23(1):67-72. doi: 10.1007/BF00205558.
Abstract
In this report, we examine the antigen nonspecific immunoregulating activity of macrophages isolated from the murine methylcholanthrene-induced fibrosarcoma FSA. These cells were shown to enhance the primary anti-CRBC PFC response of whole normal spleen cells in a dose-dependent fashion. This function was associated with a subpopulation of large Ia-negative macrophages and was mediated by a soluble macrophage-derived factor that appeared to act by stimulating the proliferation and/or differentiation of antigen-reactive T cells. The relationship of this factor to previously described monokines is discussed.
摘要
在本报告中，我们研究了从小鼠甲基胆蒽诱导的纤维肉瘤FSA中分离出的巨噬细胞的抗原非特异性免疫调节活性。这些细胞被证明能以剂量依赖的方式增强全正常脾细胞的原发性抗CRBC PFC反应。该功能与一大群Ia阴性巨噬细胞亚群有关，并由一种可溶性巨噬细胞衍生因子介导，该因子似乎通过刺激抗原反应性T细胞的增殖和/或分化起作用。讨论了该因子与先前描述的单核因子的关系。
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本文引用的文献
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Interleukin 1 is more than an interleukin.白细胞介素1不仅仅是一种白细胞介素。
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Cellular interactions in thymus-dependent antibody responses.胸腺依赖性抗体应答中的细胞相互作用。
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The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.巨噬细胞在抗原刺激中的调节作用。第二部分：淋巴细胞与巨噬细胞之间的共生关系。
Adv Immunol. 1981;31:1-136. doi: 10.1016/s0065-2776(08)60919-0.
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Macrophages and neoplasms: new insights and their implication in tumor immunobiology.巨噬细胞与肿瘤：新见解及其在肿瘤免疫生物学中的意义
Cancer Metastasis Rev. 1982;1(3):227-39. doi: 10.1007/BF00046829.
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The effects of interleukin 1 on human B cell activation and proliferation.白细胞介素1对人B细胞活化和增殖的影响。
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The activation state of macrophage subpopulations from a murine fibrosarcoma.来自小鼠纤维肉瘤的巨噬细胞亚群的激活状态。
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Antigen presentation: comments on its regulation and mechanism.抗原呈递：关于其调控与机制的述评
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