Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, U.K.
Clin Sci (Lond). 2021 Oct 15;135(19):2265-2283. doi: 10.1042/CS20210127.
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern, with rising incidence alongside high morbidity and mortality. However, the pathophysiology of HFpEF is not yet fully understood. The association between HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid accumulation and subsequent lipotoxicity.
射血分数保留的心力衰竭（HFpEF）是一个日益严重的公共卫生问题，其发病率不断上升，同时伴有高发病率和死亡率。然而，HFpEF 的病理生理学尚未完全了解。HFpEF 与代谢综合征（MetS）之间的关联表明，脂质代谢失调可能导致舒张功能障碍和随后的 HFpEF。本文总结了 MetS 背景下 HFpEF 发病机制的最新进展，重点关注脂质处理受损、心肌脂质蓄积和随后的脂毒性。
