Center for Neural Science, New York University, New York, NY 10003, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Center for Neural Science, New York University, New York, NY 10003, USA.
Neuron. 2021 Nov 3;109(21):3521-3534.e6. doi: 10.1016/j.neuron.2021.09.032. Epub 2021 Oct 12.
The hippocampal formation is linked to spatial navigation, but there is little corroboration from freely moving primates with concurrent monitoring of head and gaze stances. We recorded neural activity across hippocampal regions in rhesus macaques during free foraging in an open environment while tracking their head and eye. Theta activity was intermittently present at movement onset and modulated by saccades. Many neurons were phase-locked to theta, with few showing phase precession. Most neurons encoded a mixture of spatial variables beyond place and grid tuning. Spatial representations were dominated by facing location and allocentric direction, mostly in head, rather than gaze, coordinates. Importantly, eye movements strongly modulated neural activity in all regions. These findings reveal that the macaque hippocampal formation represents three-dimensional (3D) space using a multiplexed code, with head orientation and eye movement properties being dominant during free exploration.
海马结构与空间导航有关，但在自由移动的灵长类动物中，很少有同时监测头部和注视姿势的证据来证实这一点。我们在开放环境中记录了恒河猴在自由觅食过程中海马区域的神经活动，同时跟踪它们的头部和眼睛。θ 活动在运动开始时间歇性出现，并受扫视调节。许多神经元与θ 锁相，很少有相位超前。大多数神经元编码了除位置和网格调谐之外的混合空间变量。空间表示主要由面对位置和以自我为中心的方向主导，主要在头部而不是在眼睛坐标中。重要的是，眼球运动强烈调节所有区域的神经活动。这些发现表明，猕猴海马结构使用复用代码来表示三维（3D）空间，在自由探索期间，头部方向和眼球运动特性占主导地位。
