Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China; Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, PR China.
Sleep Med. 2021 Nov;87:233-240. doi: 10.1016/j.sleep.2021.09.013. Epub 2021 Sep 27.
The purposes of the present study were to explore independent and interactive associations between night sleep duration, night sleep quality and coronary heart disease (CHD) based on a rural population in China.
A total of 27,935 participants (11,177 men and 16,758 women) were investigated from the Henan Rural Cohort. Information about sleep was assessed by using the Pittsburgh Sleep Quality Index (PSQI). Restricted cubic splines and logistic regression were used to estimate the relationship between night sleep duration and quality with CHD.
Among the 27,935 participants, 1506 participants with CHD were identified. Compared with participants with scores lower than 3, the odds ratios (ORs) and 95% confidence intervals (95% CIs) of participants with score of 3-5, 6-8, ≥9 were respectively 1.42 (1.24-1.63), 1.99 (1.70-2.33), and 2.56 (2.13-3.08) with full adjustment of covariates. Compared with night sleep duration of 7 h, men and women who slept less than 5 h were 1.55 (1.11-2.17), 1.12 (0.59-2.12) and 1.80 (1.20-2.68), after being adjusted ORs (95% CIs) of the total. Moreover, the ORs and 95% CIs of CHD increased with the shortening of sleep duration at PSQI score above the highlighted levels.
Poor sleep quality and short night sleep duration were all associated with CHD in Chinese rural areas. Moreover, the association was more obvious in women. In addition, the strongest prevalence of CHD was found in short sleepers with poor sleep quality.
本研究旨在基于中国农村人群，探讨夜间睡眠时间和睡眠质量与冠心病（CHD）的独立和交互关联。
共纳入来自河南农村队列的 27935 名参与者（男性 11177 名，女性 16758 名）。采用匹兹堡睡眠质量指数（PSQI）评估睡眠情况。采用限制性立方样条和 logistic 回归估计夜间睡眠时间和睡眠质量与 CHD 的关系。
在 27935 名参与者中，共确定了 1506 名 CHD 患者。与 PSQI 评分＜3 分的参与者相比，PSQI 评分 3-5 分、6-8 分、≥9 分的参与者发生 CHD 的比值比（OR）及其 95%置信区间（95%CI）分别为 1.42（1.24-1.63）、1.99（1.70-2.33）和 2.56（2.13-3.08），且经多变量校正后差异仍有统计学意义。与夜间睡眠 7 h 相比，睡眠时间＜5 h 的男性和女性发生 CHD 的 OR（95%CI）分别为 1.55（1.11-2.17）、1.12（0.59-2.12）和 1.80（1.20-2.68）。此外，PSQI 评分高于临界值时，随着睡眠持续时间的缩短，CHD 的 OR 值及其 95%CI 逐渐增加。
中国农村地区较差的睡眠质量和较短的夜间睡眠时间均与 CHD 相关，且女性人群中相关性更明显。此外，睡眠质量差且睡眠时间短的人群 CHD 患病率最高。
