Li Cun, Luo Shun-Xin, Liang Tian-Wei, Song Dan, Fu Jin-Xiao
School of Clinical Medicine, Dali University, Dali, Yunnan, China.
Geriatric Department, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China.
Front Cardiovasc Med. 2025 Mar 25;12:1452006. doi: 10.3389/fcvm.2025.1452006. eCollection 2025.
The influence of extreme sleep duration on coronary heart disease (CHD) risk across genders remains a debated topic.
This analysis gathers observational studies that explore association between varying sleep durations and CHD risks. Trend estimation employs generalized least squares, converting specific category risk estimates into relative risks (RR) per hour of sleep increase. A two-stage hierarchical regression model evaluates potential linear dose-response relationships. Data analysis utilizes random-effects restricted cubic spline models with four knots.
Involving 17 studies and 906,908 participants, this meta-analysis identifies a pronounced U-shaped nonlinear relationship between sleep duration and CHD risk applicable to both genders ( < 0.01). Notably, shorter sleep durations are linked to higher CHD risks in women, whereas longer durations are more consequential for men. The optimal sleep duration for minimizing CHD risk is between 7.0-8.0 h daily for men and 7.5-8.5 h for women.
The influence of sleep duration on CHD risk differs significantly between genders.
https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier (CRD42023478235).
极端睡眠时间对不同性别的冠心病（CHD）风险的影响仍是一个有争议的话题。
本分析收集了探索不同睡眠时间与冠心病风险之间关联的观察性研究。趋势估计采用广义最小二乘法，将特定类别风险估计值转换为每增加一小时睡眠的相对风险（RR）。两阶段分层回归模型评估潜在的线性剂量反应关系。数据分析采用具有四个节点的随机效应受限立方样条模型。
这项荟萃分析涉及17项研究和906908名参与者，确定了睡眠时间与冠心病风险之间存在明显的U型非线性关系，这适用于男女两性（<0.01）。值得注意的是，较短的睡眠时间与女性较高的冠心病风险相关，而较长的睡眠时间对男性影响更大。将冠心病风险降至最低的最佳睡眠时间，男性为每天7.0 - 8.0小时，女性为7.5 - 8.5小时。
睡眠时间对冠心病风险的影响在不同性别之间存在显著差异。
https://www.crd.york.ac.uk/PROSPERO/myprospero，标识符（CRD42023478235）。
