Department of Gynecology, The Second People's Hospital of Rizhao, Rizhao, Shandong, China.
Department of Obstetrics and Gynecology, The Second People's Hospital of Dongying, Dongying, Shandong, China.
Clinics (Sao Paulo). 2021 Oct 11;76:e2671. doi: 10.6061/clinics/2021/e2671. eCollection 2021.
To investigate the predictive value of long non-coding RNA (lncRNA) H19 and the ten-eleven translocation enzyme 1 (TET1) transcriptional expression in postoperative recurrence of uterine fibroids (UFs).
Seventy-five patients with UF, who underwent surgical treatment, were enrolled in the treatment group, and 60 healthy individuals were enrolled in the control group. The relative expression levels of lncRNA H19 and TET1 mRNA in the serum and UF tissues were analyzed. The patients were further divided into a better curative (BC) group and a poor efficacy (PE) group to analyze the predictive value of lncRNA H19 and TET1 and the independent risk factors affecting the recurrence of UF.
Compared with the control group, lncRNA H19 expression levels were significantly higher, while TET1 expression levels were significantly lower in the treatment group (p<0.001). The area under the receiver operating characteristic (ROC) curve (AUC) values of the two indicators for diagnostic importance were found to be 0.872 and 0.826, respectively. Compared with the PE group, lncRNA H19 expression levels were significantly lower, while TET1 expression levels were significantly higher in the BC group (p<0.001). The AUC values of the two indicators for their predictive efficacy were 0.788 and 0.812, respectively. Logistic regression analysis showed that age, menarche age, maximum diameter of UFs, number of UFs, lncRNA H19 levels, and TET1 levels were independent risk factors affecting UF recurrence. The AUC values of lncRNA H19 and TET1 for their predictive value for postoperative recurrence were 0.814 and 0.765, respectively.
The lncRNA H19 and TET1 have high diagnostic and predictive efficacy for determining the postoperative recurrence of UFs.
探讨长链非编码 RNA（lncRNA）H19 和 ten-eleven translocation 酶 1（TET1）转录表达对子宫肌瘤（UFs）术后复发的预测价值。
纳入 75 例行手术治疗的 UF 患者为治疗组，另纳入 60 例健康个体为对照组。分析血清和 UF 组织中 lncRNA H19 和 TET1 mRNA 的相对表达水平。进一步将患者分为疗效较好（BC）组和疗效较差（PE）组，分析 lncRNA H19 和 TET1 的预测价值及影响 UF 复发的独立危险因素。
与对照组相比，治疗组 lncRNA H19 表达水平显著升高，TET1 表达水平显著降低（p<0.001）。两指标诊断重要性的受试者工作特征（ROC）曲线下面积（AUC）值分别为 0.872 和 0.826。与 PE 组相比，BC 组 lncRNA H19 表达水平显著降低，TET1 表达水平显著升高（p<0.001）。两指标预测效能的 AUC 值分别为 0.788 和 0.812。Logistic 回归分析显示，年龄、初潮年龄、UFs 最大直径、UFs 数量、lncRNA H19 水平和 TET1 水平是影响 UF 复发的独立危险因素。lncRNA H19 和 TET1 对术后复发的预测价值的 AUC 值分别为 0.814 和 0.765。
lncRNA H19 和 TET1 对 UF 术后复发具有较高的诊断和预测效能。
