Dierenkliniek Plantijn, Antwerpen, Belgium.
Institut für Tierpathologie der Universität Bern, Switzerland.
Vet Dermatol. 1998 Jun;9(2):127-134. doi: 10.1046/j.1365-3164.1998.00095.x.
This report presents a case of paraneoplastic pemphigus in a 7-year-old female Bouvier. The dog initially showed extensive oral ulcerations that exacerbated upon treatment with trimethoprim-sulfadiazine. Subsequently, the dog developed vesiculobullous and ulcerative lesions on the ear margins, the nose, periocular, and at the nail beds. Due to complete therapy resistance and a deteriorating general condition, the dog was euthanized. During post-mortem examination a thymic lymphoma was found. While an early biopsy of the oral cavity revealed features of erythema multiforme, skin lesions at necropsy were typical of pemphigus vulgaris. Indirect immunofluorescence of patient serum revealed an antikeratinocyte membrane pattern typical for pemphigus. The serum was also positive on bovine bladder epithelium. In a Western blot, autoantibodies to a 210 and a 190 kDa protein were detected.
本报告介绍了一例7岁雌性布维耶犬的副肿瘤性天疱疮病例。这只狗最初出现广泛的口腔溃疡，在用甲氧苄啶-磺胺嘧啶治疗后病情加重。随后，狗在耳缘、鼻子、眼周和甲床出现水疱大疱性和溃疡性病变。由于完全耐药且全身状况恶化，这只狗被实施安乐死。尸检时发现胸腺淋巴瘤。虽然早期口腔活检显示有多形红斑的特征，但尸检时的皮肤病变是寻常型天疱疮的典型表现。患者血清的间接免疫荧光显示出天疱疮典型的抗角质形成细胞膜模式。血清对牛膀胱上皮也呈阳性。在蛋白质印迹法中，检测到针对210 kDa和190 kDa蛋白的自身抗体。
