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犬皮肤综合征的非侵入性临床辅助诊断

Non-Invasive Paraclinical Diagnosis of Hepatocutaneous Syndrome in a Dog.

作者信息

Strichea Anamaria-Hortensia, Hreniuc Ștefania Livia, Solcan Gheorghe

机构信息

Internal Medicine Clinic, Faculty of Veterinary Medicine, Iași University of Life Sciences, 8 M. Sadoveanu Alley, 700489 Iași, Romania.

Diagnostic Imaging Clinic, Faculty of Veterinary Medicine, Iași University of Life Sciences, 8 M. Sadoveanu Alley, 700489 Iași, Romania.

出版信息

Life (Basel). 2024 Jul 8;14(7):853. doi: 10.3390/life14070853.

DOI:10.3390/life14070853
PMID:39063607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11277621/
Abstract

A 14-year-old, female spayed Bichon Maltese with no other known previous pathologies was presented for dermatological examination after being referred from a private clinic with the suspicion of generalized, treatment-resistant demodicosis. Upon presentation and clinical examination, multiple deep skin scrapings were performed, returning negative parasitological results. Complete blood count and serum biochemistry revealed mild hepatic damage. Abdominal ultrasound revealed an abnormal echostructure of the liver displaying a honeycomb or Swiss cheese-like pattern, reported as pathognomonic for hepatocutaneous syndrome. The owner declined any further paraclinical examination, including skin biopsy and histopathological examination, requesting a treatment protocol that could be pursued at home, considering the age of the dog and its reactive behavior during the examination. The present case report highlights a non-invasive method of diagnosing the hepatocutaneous syndrome in a dog by clinical examination, routine blood testing, and ultrasound assessment of the abdomen, in the absence of the possibility of doing a histopathological diagnosis.

摘要

一只14岁已绝育的比熊马尔济斯母犬,此前无其他已知病史,因被一家私人诊所怀疑患有全身性、难治性蠕形螨病而转诊来进行皮肤科检查。就诊时进行临床检查,多次进行深部皮肤刮片,寄生虫学检查结果为阴性。全血细胞计数和血清生化检查显示轻度肝损伤。腹部超声显示肝脏回声结构异常,呈蜂窝状或瑞士奶酪样模式,这被报告为肝皮肤综合征的特征性表现。由于考虑到犬的年龄及其在检查过程中的应激行为,主人拒绝了包括皮肤活检和组织病理学检查在内的任何进一步的辅助临床检查,要求提供一种可以在家中进行的治疗方案。本病例报告强调了在无法进行组织病理学诊断的情况下,通过临床检查、常规血液检测和腹部超声评估对犬肝皮肤综合征进行非侵入性诊断的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/c42c29981d9d/life-14-00853-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/a51791891fb3/life-14-00853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/e1ae41e64649/life-14-00853-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/c42c29981d9d/life-14-00853-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/3f80fe3055d0/life-14-00853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/32db21ce6c93/life-14-00853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/dc57a7b55703/life-14-00853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/81083111f2ee/life-14-00853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/a51791891fb3/life-14-00853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/e1ae41e64649/life-14-00853-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de5/11277621/c42c29981d9d/life-14-00853-g007.jpg

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本文引用的文献

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J Vet Intern Med. 2022 Jan;36(1):106-115. doi: 10.1111/jvim.16323. Epub 2021 Nov 25.
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Paraneoplastic pemphigus in a dog.犬副肿瘤性天疱疮
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Clinical features and amino acid profiles of dogs with hepatocutaneous syndrome or hepatocutaneous-associated hepatopathy.具有肝性皮肤病综合征或肝性皮肤病相关肝病的犬只的临床特征和氨基酸谱。
J Vet Intern Med. 2022 Jan;36(1):97-105. doi: 10.1111/jvim.16259. Epub 2021 Sep 2.
4
Zinc in Dog Nutrition, Health and Disease: A Review.犬类营养、健康与疾病中的锌:综述
Animals (Basel). 2021 Apr 1;11(4):978. doi: 10.3390/ani11040978.
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Approach to the Diagnosis of Hepatocutaneous Syndrome in Dogs: A Retrospective Study and Literature Review.犬肝性皮肤病综合征的诊断方法:一项回顾性研究和文献综述。
J Am Anim Hosp Assoc. 2021 Jan 1;57(1):15-25. doi: 10.5326/JAAHA-MS-7072.
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Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review.犬、猫和马的深部天疱疮(寻常型天疱疮、增殖型天疱疮和副肿瘤性天疱疮):全面综述。
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