Assarzadegan Naziheh, Brooks Eugene, Voltaggio Lysandra
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pathology. 2022 Mar;54(2):184-194. doi: 10.1016/j.pathol.2021.07.003. Epub 2021 Oct 10.
A host of human papillomavirus (HPV)-associated squamous and glandular lesions may be identified in the anal canal in men and women. Given their relative rarity, familiarity with the morphological spectrum associated with HPV-driven anal neoplasia is important for proper identification and diagnosis. In this article, we review the classification and basic histopathological features of HPV-related squamous intraepithelial and invasive lesions as well as associated pitfalls. In addition, we provide an update on recently described HPV-driven, non-squamous tumours. As our experience with these lesions evolves, we expect the histological spectrum to further expand, particularly as it relates to non-squamous HPV-driven neoplasia.
男性和女性的肛管中可发现一系列与人类乳头瘤病毒（HPV）相关的鳞状和腺性病变。鉴于其相对罕见性，熟悉与HPV驱动的肛门肿瘤形成相关的形态学谱系对于正确识别和诊断很重要。在本文中，我们回顾了HPV相关的鳞状上皮内病变和浸润性病变的分类及基本组织病理学特征，以及相关的陷阱。此外，我们提供了最近描述的HPV驱动的非鳞状肿瘤的最新情况。随着我们对这些病变的经验不断发展，我们预计组织学谱系会进一步扩展，特别是与非鳞状HPV驱动的肿瘤形成相关的谱系。
