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美国国家航空航天局的地面微重力模拟设施。

NASA's Ground-Based Microgravity Simulation Facility.

机构信息

NASA John F. Kennedy Space Center, Merritt Island, FL, USA.

LASSO Contract, URS Federal Services, Inc., Germantown, MD, USA.

出版信息

Methods Mol Biol. 2022;2368:281-299. doi: 10.1007/978-1-0716-1677-2_18.

DOI:10.1007/978-1-0716-1677-2_18
PMID:34647262
Abstract

Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogs have been widely used in space biology ground studies. Even though microgravity simulators do not produce all of the biological effects observed in the true microgravity environment, they provide alternative test platforms that are effective, affordable, and readily available to facilitate microgravity research. The Microgravity Simulation Support Facility (MSSF) at the National Aeronautics and Space Administration (NASA) John F. Kennedy Space Center (KSC) has been established for conducting short duration experiments, typically less than 1 month, utilizing a variety of microgravity simulation devices for research at different gravity levels. The simulators include, but are not limited to, 2D Clinostats, 3D Clinostats, Random Positioning Machines, and Rotating Wall Vessels. In this chapter, we will discuss current MSSF capabilities, development concepts, and the physical characteristics of these microgravity simulators.

摘要

由于在太空中进行实验的机会稀缺,各种微重力模拟器和模拟物已被广泛应用于空间生物学地面研究。尽管微重力模拟器无法产生在真实微重力环境中观察到的所有生物学效应,但它们提供了替代的测试平台,这些平台具有有效性、经济性和可及性,有助于开展微重力研究。美国国家航空航天局(NASA)约翰·F·肯尼迪航天中心(KSC)的微重力模拟支持设施(MSSF)已经建立,用于进行短期实验,通常不到 1 个月,利用各种微重力模拟设备在不同重力水平下进行研究。这些模拟器包括但不限于二维回旋器、三维回旋器、随机定位机和旋转壁容器。在本章中,我们将讨论当前 MSSF 的能力、发展概念以及这些微重力模拟器的物理特性。

相似文献

1
NASA's Ground-Based Microgravity Simulation Facility.美国国家航空航天局的地面微重力模拟设施。
Methods Mol Biol. 2022;2368:281-299. doi: 10.1007/978-1-0716-1677-2_18.
2
Use of Reduced Gravity Simulators for Plant Biological Studies.利用微重力模拟器进行植物生物学研究。
Methods Mol Biol. 2022;2368:241-265. doi: 10.1007/978-1-0716-1677-2_16.
3
Space Station Biological Research Project.空间站生物研究项目。
Gravit Space Biol Bull. 1997 Jun;10(2):137-43.
4
Use of microgravity simulators for plant biological studies.微重力模拟器在植物生物学研究中的应用。
Methods Mol Biol. 2015;1309:239-54. doi: 10.1007/978-1-4939-2697-8_18.
5
Neurosciences research in space: future directions.太空神经科学研究:未来方向
Acta Astronaut. 1991;23:289-93. doi: 10.1016/0094-5765(91)90130-w.
6
Analysis of peg formation in cucumber seedlings grown on clinostats and in a microgravity (space) environment.在回转器上以及微重力(太空)环境中生长的黄瓜幼苗中栓形成的分析。
J Plant Res. 1999 Dec;112(1108):507-16. doi: 10.1007/pl00013907.
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Comparative effectiveness of a clinostat and a slow-turning lateral vessel at mimicking the ultrastructural effects of microgravity in plant cells.回转器和缓慢旋转横向容器在模拟微重力对植物细胞超微结构影响方面的比较效果。
Ann Bot. 1990;66:541-9. doi: 10.1093/oxfordjournals.aob.a088063.
8
Erythroid cell growth and differentiation in vitro in the simulated microgravity environment of the NASA rotating wall vessel bioreactor.在美国国家航空航天局旋转壁式生物反应器模拟微重力环境下的体外红系细胞生长与分化。
In Vitro Cell Dev Biol Anim. 2001 Feb;37(2):79-83. doi: 10.1290/1071-2690(2001)037<0079:ECGADI>2.0.CO;2.
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Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology.地面模拟微重力设施:特定生物体使用的建议,以及推荐的术语。
Astrobiology. 2013 Jan;13(1):1-17. doi: 10.1089/ast.2012.0876. Epub 2012 Dec 19.
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KC-135 flights for life science activities.用于生命科学活动的KC - 135航班。
ASGSB Bull. 1992 Oct;6(1):107-12.

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Technology using simulated microgravity.使用模拟微重力的技术。
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Choroidal circulation disturbance is an initial factor in outer retinal degeneration in rats under simulated weightlessness.脉络膜循环紊乱是模拟失重状态下大鼠视网膜外层变性的初始因素。

本文引用的文献

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PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity.PTEN/FOXO3/AKT 通路调节细胞死亡,并介导结直肠癌细胞在模拟微重力下的形态发生分化。
Sci Rep. 2017 Jul 20;7(1):5952. doi: 10.1038/s41598-017-06416-4.
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Fluid Dynamics Appearing during Simulated Microgravity Using Random Positioning Machines.使用随机定位机模拟微重力时出现的流体动力学
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10
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