Hershko C, Nesher G, Yinnon A M, Zandman-Goddard G, Klutstein M, Abrahamov A, Alon I, Rudensky B, Isacsohn M
J Trop Med Hyg. 1986 Jun;89(3):107-12.
Within a 2 month period 131 Ethiopian immigrants were admitted for treatment at a general hospital in Jerusalem. There were 52 patients with malaria, 13 with typhoid fever, 24 with pneumonia, seven with tuberculosis, nine with shigella and 11 with campylobacter. Over three-quarters of these patients were anaemic. In the majority of cases anaemia was normocytic and was most probably secondary to malaria and other intercurrent infections. The prevalence of diffuse non-toxic goitre was 7% in children and 19% in adults with a male to female ratio of 4:13. A positive rapid plasma reagin (RPR) test was found in 4% of sera tested and a positive HBsAg in 13%. IgG antibodies to HBc antigen were found in 75% of subjects. All patients with infectious diseases responded to therapy and, despite their poor condition at arrival, there were no fatalities and no late sequelae. The high HBsAg carrier state calls attention to the risk of vertical transmission by infected mothers and underlines the need for active immunization of infants at risk. The high prevalence of untreated tuberculosis and malaria poses a potential public health hazard, but with the current systematic screening of this population leading to identification and effective treatment of affected subjects, chances for the practical eradication of malaria and tuberculosis are excellent. Finally, the large scale transfer of a population from rural Africa to a modern and largely urban society presents a unique opportunity for a prospective study of the impact of environment on the emergence of diseases which plague modern society such as diabetes, atherosclerotic cardiovascular disease, hypertension and cancer.
在两个月的时间里,131名埃塞俄比亚移民被送往耶路撒冷的一家综合医院接受治疗。其中有52例疟疾患者、13例伤寒患者、24例肺炎患者、7例肺结核患者、9例志贺菌感染患者和11例弯曲杆菌感染患者。这些患者中超过四分之三患有贫血。在大多数情况下,贫血为正细胞性,很可能继发于疟疾和其他并发感染。弥漫性非毒性甲状腺肿的患病率在儿童中为7%,在成人中为19%,男女比例为4:13。在检测的血清中,4%的快速血浆反应素(RPR)试验呈阳性,13%的乙肝表面抗原(HBsAg)呈阳性。75%的受试者检测到抗乙肝核心抗原(HBc)的IgG抗体。所有传染病患者对治疗均有反应,尽管他们入院时病情不佳,但无一例死亡,也无晚期后遗症。高HBsAg携带状态提醒人们注意受感染母亲垂直传播的风险,并强调有必要对高危婴儿进行主动免疫。未经治疗的肺结核和疟疾的高患病率构成了潜在的公共卫生危害,但通过目前对这一人群的系统筛查,能够识别并有效治疗受影响的个体,疟疾和肺结核实际根除的可能性很大。最后,大量人口从非洲农村大规模转移到一个现代化且主要为城市的社会,为前瞻性研究环境对困扰现代社会的疾病(如糖尿病、动脉粥样硬化性心血管疾病、高血压和癌症)出现的影响提供了独特的机会。