Department of Internal Medicine I, Bashkir State Medical University, Ufa, Russian Federation.
Department of Biomedical Engineering of Ufa State Aviation Technical University, Ufa, Russian Federation.
PLoS One. 2021 Oct 14;16(10):e0257982. doi: 10.1371/journal.pone.0257982. eCollection 2021.
J-waves represent a common finding in routine ECGs (5-6%) and are closely linked to ventricular tachycardias. While arrhythmias and non-specific ECG alterations are a frequent finding in COVID-19, an analysis of J-wave incidence in acute COVID-19 is lacking.
A total of 386 patients consecutively, hospitalized due to acute COVID-19 pneumonia were included in this retrospective analysis. Admission ECGs were analyzed, screened for J-waves and correlated to clinical characteristics and 28-day mortality.
J-waves were present in 12.2% of patients. Factors associated with the presence of J-waves were old age, female sex, a history of stroke and/or heart failure, high CRP levels as well as a high BMI. Mortality rates were significantly higher in patients with J-waves in the admission ECG compared to the non-J-wave cohort (J-wave: 14.9% vs. non-J-wave 3.8%, p = 0.001). After adjusting for confounders using a multivariable cox regression model, the incidence of J-waves was an independent predictor of mortality at 28-days (OR 2.76 95% CI: 1.15-6.63; p = 0.023). J-waves disappeared or declined in 36.4% of COVID-19 survivors with available ECGs for 6-8 months follow-up.
J-waves are frequently and often transiently found in the admission ECG of patients hospitalized with acute COVID-19. Furthermore, they seem to be an independent predictor of 28-day mortality.
J 波在常规心电图中较为常见（占 5%-6%），与室性心动过速密切相关。虽然心律失常和非特异性心电图改变在 COVID-19 中较为常见，但急性 COVID-19 中 J 波发生率的分析尚缺乏。
本回顾性分析共纳入了 386 例连续因急性 COVID-19 肺炎住院的患者。分析入院时的心电图，筛选 J 波，并将其与临床特征和 28 天死亡率相关联。
J 波在 12.2%的患者中存在。与 J 波存在相关的因素包括年龄较大、女性、中风和/或心力衰竭史、高 CRP 水平以及高 BMI。入院心电图存在 J 波的患者死亡率明显高于无 J 波的患者（J 波：14.9% vs. 非 J 波：3.8%，p = 0.001）。使用多变量 Cox 回归模型调整混杂因素后，J 波的发生率是 28 天死亡率的独立预测因素（OR 2.76，95%CI：1.15-6.63；p = 0.023）。在有 6-8 个月随访的心电图可用的 COVID-19 幸存者中，36.4%的 J 波消失或降低。
J 波在急性 COVID-19 住院患者的入院心电图中频繁出现，且往往是短暂性的。此外，它们似乎是 28 天死亡率的独立预测因素。
