严重急性呼吸综合征冠状病毒2（SARS-CoV-2）诱导肺细胞衰老的证据：对冠状病毒病（COVID-19）肺部疾病的潜在影响 - Suppr

Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.

作者信息

Lipskaia Larissa, Maisonnasse Pauline, Fouillade Charles, Sencio Valentin, Pascal Quentin, Flaman Jean-Michel, Born Emmanuelle, Londono-Vallejo Arturo, Le Grand Roger, Bernard David, Trottein François, Adnot Serge

机构信息

Paris-East Créteil University Créteil, France.

AP-HP-Hôpital Henri Mondor Créteil, France.

出版信息

Am J Respir Cell Mol Biol. 2022 Jan;66(1):107-111. doi: 10.1165/rcmb.2021-0205LE.

DOI:10.1165/rcmb.2021-0205LE

PMID:34648725

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8803362/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b9/8803362/fb558ad2c69b/rcmb.2021-0205LEf1.jpg

相似文献

Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.

Am J Respir Cell Mol Biol. 2022 Jan;66(1):107-111. doi: 10.1165/rcmb.2021-0205LE.

SARS-CoV-2 pneumonia-receptor binding and lung immunopathology: a narrative review.

Crit Care. 2021 Feb 8;25(1):53. doi: 10.1186/s13054-020-03399-z.

First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)".

Infection. 2021 Feb;49(1):63-73. doi: 10.1007/s15010-020-01499-0. Epub 2020 Oct 1.

The spatial landscape of lung pathology during COVID-19 progression.

Nature. 2021 May;593(7860):564-569. doi: 10.1038/s41586-021-03475-6. Epub 2021 Mar 29.

The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues.

Viruses. 2021 Aug 23;13(8):1673. doi: 10.3390/v13081673.

Virus-induced senescence is a driver and therapeutic target in COVID-19.

Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13.

Lung microbiota and COVID-19 severity.

Nat Microbiol. 2021 Oct;6(10):1217-1218. doi: 10.1038/s41564-021-00969-x.

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.

J Virol. 2022 Jan 12;96(1):e0151121. doi: 10.1128/JVI.01511-21. Epub 2021 Oct 20.

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.

Nature. 2021 Jan;589(7843):603-607. doi: 10.1038/s41586-020-2943-z. Epub 2020 Nov 9.

ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques.

Cell Mol Immunol. 2021 May;18(5):1308-1310. doi: 10.1038/s41423-021-00672-1. Epub 2021 Apr 1.

引用本文的文献

Virus-Induced Cellular Senescence Causes Pulmonary Sequelae Post-Influenza Infection.

Aging Cell. 2025 Sep;24(9):e70140. doi: 10.1111/acel.70140. Epub 2025 Jun 20.

A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions.

Nat Aging. 2025 May 29. doi: 10.1038/s43587-025-00886-2.

A Dual Role of the Senescence Marker P16Ink4a in Liver Endothelial Cell Function.

Cells. 2024 Nov 21;13(23):1929. doi: 10.3390/cells13231929.

Cellular senescence in acute human infectious disease: a systematic review.

Front Aging. 2024 Nov 15;5:1500741. doi: 10.3389/fragi.2024.1500741. eCollection 2024.

Cdc42 improve SARS-CoV-2 spike protein-induced cellular senescence through activating of Wnt/β-Catenin signaling pathway.

Front Cell Infect Microbiol. 2024 Nov 4;14:1449423. doi: 10.3389/fcimb.2024.1449423. eCollection 2024.

Loss of CFTR Reverses Senescence Hallmarks in SARS-CoV-2 Infected Bronchial Epithelial Cells.

Int J Mol Sci. 2024 Jun 4;25(11):6185. doi: 10.3390/ijms25116185.

Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment.

Cell Rep Med. 2024 May 21;5(5):101561. doi: 10.1016/j.xcrm.2024.101561. Epub 2024 May 13.

Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation.

Lung. 2024 Apr;202(2):157-170. doi: 10.1007/s00408-024-00679-1. Epub 2024 Mar 17.

Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.

Am J Respir Cell Mol Biol. 2024 May;70(5):379-391. doi: 10.1165/rcmb.2023-0429OC.

SARS-CoV-2 and the DNA damage response.

J Gen Virol. 2023 Nov;104(11). doi: 10.1099/jgv.0.001918.

本文引用的文献

Senolytics reduce coronavirus-related mortality in old mice.

Science. 2021 Jul 16;373(6552). doi: 10.1126/science.abe4832. Epub 2021 Jun 8.

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.

Cell Res. 2021 Mar;31(3):272-290. doi: 10.1038/s41422-020-00455-9. Epub 2021 Jan 21.

Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study.

Eur Respir J. 2021 Apr 29;57(4). doi: 10.1183/13993003.03690-2020. Print 2021 Apr.

The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.

Front Med (Lausanne). 2020 Oct 26;7:589553. doi: 10.3389/fmed.2020.589553. eCollection 2020.

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.

Nature. 2020 Sep;585(7826):584-587. doi: 10.1038/s41586-020-2558-4. Epub 2020 Jul 22.

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.

Nat Med. 2020 Jun;26(6):842-844. doi: 10.1038/s41591-020-0901-9. Epub 2020 May 12.

Clinical Characteristics of Coronavirus Disease 2019 in China.

N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.

Senescent cells: an emerging target for diseases of ageing.

Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus.

Virulence. 2016 May 18;7(4):427-42. doi: 10.1080/21505594.2016.1144001. Epub 2016 Jan 25.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献