副溶血性弧菌内毒素的耐受性及其他生物学特性

Tolerance and other biological properties of Vibrio parahaemolyticus endotoxins.

作者信息

Sochard M R, Colwell R R

出版信息

Jpn J Microbiol. 1976 Aug;20(4):309-19. doi: 10.1111/j.1348-0421.1976.tb00993.x.

DOI:10.1111/j.1348-0421.1976.tb00993.x

Abstract

Biological properties of endotoxins prepared from three strains of Vibrio parahaemolyticus were compared with reference to commercially prepared Salmonella typhi endotoxin. Endotoxin assays performed in rabbits included dermal Shwartzman reactivity, pyrogenicity, heat stability, and ability to induce tolerance as well as cross-tolerance. Mice were used for endotoxin LD50 determinations. Results showed V. parahaemolyticus endotoxins were similar to that of S. typhi strain O901. Induction of tolerance to V. parahaemolyticus strain 11590 endotoxin resulted in complete cross-tolerance to S. typhi endotoxin, and vice versa. Partial cross-tolerance to S. typhi endotoxin was demonstrated with rabbits rendered tolerant to endotoxin from V. parahaemolyticus strains Sak-3 and FC1011. Absorption spectra, nitrogen, phosphorus and carbohydrate analyses revealed additional similarities between endotoxins from V. parahaemolyticus and endotoxin from a member of the Enterbacteriaceae.

摘要

将从三株副溶血性弧菌制备的内毒素的生物学特性与市售伤寒沙门氏菌内毒素进行了比较。在兔子身上进行的内毒素检测包括皮肤施瓦茨曼反应性、致热性、热稳定性、诱导耐受性以及交叉耐受性的能力。使用小鼠进行内毒素LD50测定。结果表明，副溶血性弧菌内毒素与伤寒沙门氏菌O901菌株的内毒素相似。对副溶血性弧菌11590菌株内毒素诱导的耐受性导致对伤寒沙门氏菌内毒素的完全交叉耐受性，反之亦然。对来自副溶血性弧菌Sak-3和FC1011菌株内毒素产生耐受性的兔子表现出对伤寒沙门氏菌内毒素的部分交叉耐受性。吸收光谱、氮、磷和碳水化合物分析揭示了副溶血性弧菌内毒素与肠杆菌科成员的内毒素之间的其他相似之处。