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Thromboxane A2 biosynthesis during endotoxin-induced aggregation of platelets from normal and sensitized guinea-pigs.

作者信息

Bult H, Herman A G

出版信息

Agents Actions. 1979 Dec;9(5-6):560-5. doi: 10.1007/BF01968128.

DOI:10.1007/BF01968128
PMID:397765
Abstract

Endotoxin lipopolysaccharides Escherichia coli O26:B6 and E. coli O127:B8 were weak inducers of aggregation in normal guinea-pig platelet-rich plasma (PRP), even in the presence of Ca2+. Indomethacin hardly inhibited endotoxin-induced aggregation, indicating that biosynthesis of thromboxane A2 (TXA2) was of little importance. In accordance with this conclusion TXA2 was not detectable by means of bioassay during endotoxin-induced aggregation in normal guinea-pig PRP. Pretreatment of the guinea-pigs with endotoxin sensitized their PRP to endotoxin. This was due to a humoral factor with a selectively directed towards the polysaccharide moiety of endotoxin. The combination of this factor with endotoxin indued a marked biosynthesis of TXA2 and concomitant platelet aggregation.

摘要

相似文献

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THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD.利用离体器官检测循环血液中的活性物质
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Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.血栓素：一类从前列腺素内过氧化物衍生而来的新型生物活性化合物。
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Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.内过氧化物在人血小板中的生理作用：血小板环氧化酶缺乏导致的止血缺陷。
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7
Prostaglandin endoperoxides, serotonin and the superfused rabbit aorta: possible pitfalls in the bio-assay of rabbit aorta contracting substance (RCS).前列腺素内过氧化物、5-羟色胺与离体灌注兔主动脉：兔主动脉收缩物质（RCS）生物测定中可能存在的问题
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Influence of different drugs on the slow response of the intestine during the Schultz-Dale reaction.不同药物对舒尔茨-戴尔反应期间肠道慢反应的影响。
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Platelet aggregation in rabbits made tolerant to endotoxin.对内毒素产生耐受的家兔的血小板聚集情况。
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10
Endotoxin-induced platelet aggregation and secretion. I. Morphological changes and pharmacological effects.内毒素诱导的血小板聚集与分泌。I. 形态学变化及药理作用。
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