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果蝇中相邻快速和缓慢进化基因组区域之间边界的特征描述。

Characterization of the boundaries between adjacent rapidly and slowly evolving genomic regions in Drosophila.

作者信息

Martin C H, Meyerowitz E M

出版信息

Proc Natl Acad Sci U S A. 1986 Nov;83(22):8654-8. doi: 10.1073/pnas.83.22.8654.

Abstract

The site of a dramatic change in the rate of DNA sequence evolution exists near the 68C glue gene clusters of several Drosophila species. We have previously determined the approximate location of this transition site by comparison of restriction maps of the regions flanking the 68C-like glue gene cluster of five members of the melanogaster species subgroup. In the present work we report the sequence of the transition region in three of these Drosophila species: D. melanogaster, D. yakuba, and D. erecta. Using a best-fit alignment of these sequences, we find that the site of transition from slowly to rapidly evolving sequences occurs abruptly within a region less than 50 nucleotides in length. Although frequency of nucleotide substitutions changes as much as 10-fold across this boundary, frequency of small insertion/deletion events stays nearly constant.

摘要

在几种果蝇物种的68C黏胶基因簇附近,存在DNA序列进化速率发生显著变化的位点。我们之前通过比较黑腹果蝇物种亚组五个成员中类似68C黏胶基因簇两侧区域的限制性图谱,确定了这个过渡位点的大致位置。在本研究中,我们报告了其中三种果蝇物种(黑腹果蝇、雅库布果蝇和直立果蝇)过渡区域的序列。通过对这些序列进行最佳拟合比对,我们发现从缓慢进化序列到快速进化序列的过渡位点,在长度小于50个核苷酸的区域内突然出现。尽管核苷酸替换频率在这个边界两侧变化高达10倍,但小插入/缺失事件的频率几乎保持不变。

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