Zhang Tingting, Pan Na, Wang Yuping, Liu Chunyan, Hu Shimin
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Neuromodulation, Beijing, China.
Front Hum Neurosci. 2021 Sep 28;15:749162. doi: 10.3389/fnhum.2021.749162. eCollection 2021.
Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions.
非侵入性神经调节技术对脑部疾病的治疗具有重要意义。自20世纪20年代以来，人们一直在研究聚焦超声对神经元活动的影响。低强度经颅聚焦超声（tFUS）可对细胞膜和离子通道施加非破坏性机械压力效应，并已被证明可调节外周神经、脊髓反射、皮层甚至深部脑核（如丘脑）的活动。它在安全性和空间选择性方面具有明显优势。该技术被认为在神经退行性疾病和神经精神疾病的治疗中具有广阔的应用前景。这篇综述综合了动物和人体研究结果，并对tFUS在不同实验和疾病条件下的兴奋和抑制作用进行了综合描述。
