经导管动脉化疗栓塞术提高了肺癌患者的临床疗效和生活质量，并减少了不良反应。
Transcatheter arterial chemoembolization improves clinical efficacy and life quality of patients with lung cancer and reduces adverse reactions.
作者信息
Jin Shu-Qiang, Zhao Huan-Yu, Bai Bin, Ma Chun-Hui, Cao Hai-Li
机构信息
Interventional Radiography, Second Hospital Affiliated to Harbin Medical University Harbin 150086, Heilongjiang Province, China.
出版信息
Am J Transl Res. 2021 Sep 15;13(9):10396-10403. eCollection 2021.
OBJECTIVE
To determine the clinical efficacy and safety of transcatheter arterial chemoembolization (TACE) for patients with lung cancer (LC).
METHODS
A total of 513 inpatients with LC admitted to our hospital from January 2012 to January 2020 were analyzed retrospectively. Based on different treatment methods, they were assigned into a control group (CG; n=249) for traditional bronchial artery infusion (BAI) and an experimental group (EG; n=264) for TACE, with shared chemotherapy drugs and treatment courses. The two groups were compared with respect to clinical efficacy, pre- and post-treatment pulmonary function, adverse reactions, as well as negative emotions and quality of life (QoL) scores.
RESULTS
The curative effect in EG was far superior to CG (P<0.05). In comparison with CG, the pulmonary function in EG was better and the incidence of adverse reactions was lower after treatment (P<0.05). The negative emotions and the QoL were improved in both groups, with more distinct improvement in EG compared with CG (P<0.05).
CONCLUSIONS
With higher safety and efficacy, TACE can improve the clinical efficacy and QoL of patients with LC while relieving bad mood and reducing adverse reactions.
目的
确定经导管动脉化疗栓塞术（TACE）治疗肺癌（LC）患者的临床疗效和安全性。
方法
回顾性分析2012年1月至2020年1月我院收治的513例LC住院患者。根据不同治疗方法，将其分为对照组（CG；n = 249）接受传统支气管动脉灌注（BAI），实验组（EG；n = 264）接受TACE，两组化疗药物和疗程相同。比较两组的临床疗效、治疗前后肺功能、不良反应以及负面情绪和生活质量（QoL）评分。
结果
EG组疗效远优于CG组（P<0.05）。与CG组相比，EG组治疗后肺功能更好，不良反应发生率更低（P<0.05）。两组负面情绪和QoL均得到改善，EG组改善更明显，与CG组相比差异有统计学意义（P<0.05）。
结论
TACE安全性和疗效更高，可提高LC患者的临床疗效和QoL，同时缓解不良情绪，减少不良反应。
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